摘要
目的探讨乳腺癌超声征象与肿瘤分子生物学指标雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)之间的相关性。方法回顾性分析122例浸润性乳腺癌超声二维征象与肿瘤ER、PR及HER-2表达的相关性。结果本组病例ER阳性70例,PR阳性72例,HER-2过度表达38例。肿瘤形态不规则组ER及PR阳性率高于形态规则组,差异有统计学意义(P<0.05)。肿瘤边缘不光整、有毛刺或成角畸形组ER及HER-2阳性率高于边缘光整组,差异有统计学意义(P<0.05)。肿瘤内有钙化灶组ER、PR及HER-2表达阳性率均高于各自阴性组,差异均有统计学意义(P<0.05)。结论乳腺癌超声征象与ER、PR、HER-2的表达具有相关性,可在一定程度上反映乳腺癌ER、PR及HER-2的表达状态,为乳腺癌的术前辅助内分泌治疗和预后评估提供了一定的信息。
Objective To investigate whether invasive bteast cancer ultrasound features could be correlated with biological markers： estrogen receptor（ER）,progesterone receptor（PR） and human epidermal growth factor receptor-2（HER-2）.Methods We performed a retrospective review of the sonographical and biological features of women with invasive breast cancer who were admitted in our institute.Ultrasound findings（size,shape,boundary,echo pattern,echogenic halo,and presence of calcifications） of 122 breast cancers were analyzed and correlated with the tumor biological markers by univariate and multivariate logistic regression analyses.Results A total of 122 women were analysed.There were 70 cases with ER positive,72 cases with PR positive and 38 cases with HER-2 overexpression.ER and PR positive cancers displayed more frequently an irregular shape and more calcifications（P0.05）.HER-2 positive cancers also displayed more calcifications as ER and PR did（P0.05）.In univariate analysis,ER and HER-2 positive cancers had more frequently not circumscribed margins（P0.05）.Conclusion Ultrasound pattern is correlated with tumor biological markers in invasive breast cancers and it may be useful for prediction of prognosis.
出处
《临床医学》
CAS
2010年第12期37-39,共3页
Clinical Medicine
关键词
乳腺肿瘤
超声检查
性激素受体
人表皮生长因子受体-2
Breast neoplasms
Ultmsonography
Sexual hormones receptor
Human epidermal growth factor receptor-2
