摘要
病毒与宿主细胞间存在着复杂的相互作用关系,其中细胞信号通路是参与相互作用过程的重要因素。细胞外调节蛋白激酶（extracellular regu-lated protein kinases,ERK）是丝裂原活化蛋白激酶（mitogen-activated protein kinase,MAPK）信号通路家族中的一个重要信号通路。
Viruses are cell obligate parasites that take advantages of the preexisting mechanisms in the host cells for the viral amplification and pathogenesis.In the past three decades,increasing attentions have been paid to the ERK/MAPK signal cascades which play essential roles in viral infection.With regard to the virus lifecycle such as adsorption,penetration,uncoating,synthesis,assembly and release,we summarize the current research development regarding the importance of RNA virus-induced activation of ERK/MAPK signaling pathway in viral replication and pathogenesis.
出处
《中国病毒病杂志》
CAS
2012年第6期465-470,共6页
Chinese Journal of Viral Diseases
基金
国家高技术研究发展计划(863计划)项目(2007AA02Z317)
国家自然科学基金(J1030831/J0108
30470084
21172012/b020601)
