摘要
目的:检测幽门螺杆菌(Helicobacter pylori,H.pylori)在大肠癌及其癌前病变(腺瘤性息肉)中的感染情况,探讨H.pylori感染与大肠癌发病的关系.方法:肠癌组、腺瘤组、对照组各40例.肠癌组和腺瘤组分别在肠癌和腺瘤病变处活检,对照组正常大肠黏膜处活检.HE染色明确病变的组织病理学诊断,银染法检测活检黏膜H.pylori的感染情况.结果:肠癌组H.pylori检出率高于对照组,低于腺瘤组,但肠癌组与腺瘤组相比(2=0.524,P=0.469)、肠癌组与对照组相比(2=2.813,P=0.094)差异均无统计学意义(P>0.05).腺瘤组H.pylori检出率高于对照组,差异有统计学意义(2=5.591,P=0.018).结论:大肠癌与大肠腺瘤的H.pylori感染率高于正常对照组,H.pylori局部感染可能是大肠肿瘤发病的一个危险因素.
AIM： To investigate the relationship between Helicobacter pylori （H. pylori） infection and risk of colorectal carcinoma （CRC）. METHODS： Forty patients with CRC, 40 patients with colorectal adenomatous polyps （CAP）, and 40 normal controls were included. Biopsies were taken from colorectal neoplasms in patients with CRC or CAP and from normal colorectal tissue in normal controls. Pathologic diagnosis was made by hematoxylin and eosin （HE） staining. H. pylori infection was detected by silver staining.RESULTS： The detection rate of H. pylori infec tion was 27.5% in patients with CRC, 35.0% in patients with CAP, and 12.5% in normal con trols. Although the detection rate of H. pylori infection in patients with CRC was higher than those in patients with CAP and normal controls, no statistical significance was observed between them （both P 〉 0.05）. The detection rate of H. pylo r/infection in patients with CAP was significantly higher than that in normal controls （P 〈 0.05）.CONCLUSION： The detection rate of H. pylori infection in patients with colorectal neoplasms was higher than that in normal controls, indi- cating that H. pylori infection is a risk factor for colorectal neoplasms.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第28期2742-2745,共4页
World Chinese Journal of Digestology
基金
深圳市科技计划基金资助项目
No.201003067
关键词
幽门螺杆菌
结直肠癌
结直肠腺瘤
He/icobacter pylori
Colorectal carci-noma
Colorectal adenomatous polyps
