摘要
目的:比较埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法与标准三联疗法根除幽门螺杆菌(Hpylori)的疗效.方法:将我院经胃镜检查确诊为慢性胃炎和消化性溃疡且Hpylori阳性的患者79例随机分为2组,治疗组(39例)方案:前5d,埃索美拉唑20mg+阿莫西林1000mg,每日2次;后5d,埃索美拉唑20mg+克拉霉素500mg+替硝唑500mg,每日2次.对照组(40例)标准三联疗法:埃索美拉唑20mg+克拉霉素500mg+阿莫西林1000mg,每日2次,疗程7d.所有患者停药4wk后复查13C呼气试验,判断Hpylori根除率.结果:治疗组Hpylori根除率为94.87%,对照组77.50%,2组比较差异具有统计学意义(χ2=4.97,P<0.05),且序贯疗法并未增加患者的经济负担.2种方案不良方应的发生率无明显差异(χ2=0.05,P>0.05).结论:10日序贯疗法治疗Hpylori感染明显优于7日标准三联疗法,是一种安全、经济、有效的方案选择.
AIM： To determine whether the sequential therapy is better than the standard triple-drug therapy in treatment of H pylori infection for adults with chronic gastritis and peptic ulcer. METHODS： Seventy-nine patients with H pylori positive were randomly divided two groups. Thirty nine patients received a 10-day sequential therapy [esomeprazole （20 mg, twice daily） plus amoxicillin （1000 mg, twice daily） for the first 5 days, followed by esomeprazole （20 mg）, clarithromycin （500 mg） and tinidazole （500 mg） twice daily for the remaining 5 days]. Forty patients received a 7-day triple therapy [esomeprazole （20 mg）, clarithromycin （500 mg） and amoxicillin 1000 mg, twice daily]. H pylori eradi- cation was checked four weeks after treatment using 13C-urea breath test. RESULTS： The eradication rate of the 10-day sequential therapy was 94.87%, and merely 77.50% for the control group. The difference between the two groups was significant （;（2 = 4.97, P 〈0.05）. There was no difference in incidence of side effects between the two groups （X2=0.05, P 〉 0.05）. CONCLUSION： The 10-day sequential therapy achieves a higher eradication rate than the standard triple therapy for the first time in adults. It is an effective, safe and economical option for patients and possesses great potential.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第16期1693-1695,共3页
World Chinese Journal of Digestology
关键词
序贯疗法
幽门螺杆菌
三联疗法
根除率
Sequential therapy
He/icobacterpylori
Triple therapy
Eradication rate
