摘要
目的 提高肢端肥大症的治疗效果。方法 回顾分析 1984年到 1997年收治的 135例肢端肥大症 ,其中并有糖尿病 2 3例 ,并有高血压 14例 ,有肢端肥大性心肌病 5例 ;除 3例经额下入路外其余均经口鼻蝶窦入路显微手术切除肿瘤。结果 全组术后 1周内软组织肿胀均减轻乃至消失 ;12 8例进行GH复查的患者中GH下降至 5 μg/L以下者 6 6例 (5 1 6 % ) ;并有糖尿病者 2 0例血糖恢复正常 ;5例并有肢端肥大性心肌病术后心脏全部恢复正常 ;但并有高血压的患者术后血压下降不明显。全组无死亡率。结论 肢端肥大性心肌病及继发性糖尿病是肢端肥大症患者致死的主要原因 ,应严加关注 ,正确处理。
Objective To improve the effect of acromegaly treatment.Methods 135 cases of acromegaly from 1984 to 1997 were analyzed retrospectively,of which 23 cases were complicated by diabetes, 14 cases by hypertension,5 cases by acromegalic cardiomyopathy.All the cases underwent transsphenoidal microsurgical treatment except 3 cases operated via trans subfrontal approach.Results In all cases soft tissue swelling was alleviated,even disappeared in a week after operation. The concentration of GH in 128 cases was re examined. The level of GH in 66 cases (51 6%) dropped to 5μg/L below. The concentration of blood glucose returned to normal in 20 patients accompanied by diabetes. The cardiac function came to normal in all 5 cases with acromegalic cardiomyopathy after operation. Howere the decrease of blood pressure was not obvious in patients with hypertention. There was no death in this series. Conclusions Acromegalic cardiomyopathy and secondary diabetes mellitus are the primary causes leading to death. It is necessary to pay attention to them and handle them properly.
出处
《中华神经外科杂志》
CSCD
北大核心
2000年第2期69-71,共3页
Chinese Journal of Neurosurgery
关键词
肢端肥大症
并发症
心肌病
糖尿病
显微外科手术
Acromegaly Acromegalic cardiomyopathy Secondary diabetes mellitus Microsurgical treatment
