摘要
目的检测散发型白癜风患者外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平,探讨其与散发型白癜风发病的关系。方法散发型白癜风患者29例,男13例,女16例。通过流式细胞仪对散发型白癜风患者外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平进行检测,并与20例健康人相比较。结果与健康对照组相比,散发型白癜风患者外周血中CD4+/CD8+T细胞比值的差异无统计学意义(P>0.05),而CD4+CD25+调节性T细胞水平明显减少,差异有统计学意义(P<0.05),但在不同病程的患者中CD4+CD25+调节性T细胞数量的差异无统计学意义(P>0.05)。结论散发型白癜风患者外周血中存在CD4+CD25+调节性T细胞水平下降,可能与散发型白癜风的发生发展有一定关系。
Objective To detect the CD4^＋/CD8^＋ T lymphocyte ratio and the CD4^＋CD25^＋ Treg level in peripheral blood of patients with sporadic vitiligo,and to investigate its role in the pathogenesis of sporadic vitiligo.Methods Peripheral blood samples were taken from 29 outpatients with sporadic vitiligo,including 13 males and 16 females.The CD4^＋/CD8^＋ T lymphocyte ratio and the CD4^＋CD25^＋ Treg level was detected in peripheral blood of patients with sporadic vitiligo by flow cytometry,as well as controlled samples from 20 healthy human.Results There was no difference on the ratio of CD4＋/CD8＋ T lymphocyte between the patients with sporadic vitiligo and healthy people（P0.05）.Compared to the controlled group,the proportion of CD4＋CD25＋ Treg was significantly lower in sporadic vitiligo patients（P0.05）,but there was no significant difference among the groups of different courses with sporadic vitiligo（P0.05）.Conclusion The level of CD4^＋CD25^＋ Treg is lower in peripheral blood of sporadic vitiligo patients,which might play a role in the pathogenesis and development of sporadic vitiligo.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2012年第5期281-283,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
