摘要
目的 :探讨唾液酸 ( SA)、多胺 ( PA)、癌胚抗原 ( CEA)和糖蛋白抗原 2 4 2 ( CA2 4 2 )等肿瘤标记物 ( TM)单项和多项联合检测在大肠癌定性诊断中的价值。 方法 :应用 HP% M高效液相色谱仪和HP1 0 4 0 A荧光检测器或酶联免疫吸附法测定 70例大肠癌和 68例健康成人血清中的 SA、PA、CEA、CA2 4 2水平 ,分别计算单项和多项 TM联合检测对大肠癌的敏感性、特异性、阳性预测率、阴性预测率和总有效率。结果 :4种 TM在大肠癌病人中均较健康成人显著升高 ,单项指标以 CA2 4 2的诊断价值最高 ,其次是 PA。 4种 TM联合检测 ,其敏感性明显升高 ,SA+ PA+ CA2 4 2组合敏感性可达 1 0 0 % ,但特异性为 63.46%。 结论 :4种 TM均是诊断大肠癌的有价值的标记物 ,多项指标联合检测提高了检测敏感性 ,可作为人群筛查大肠癌的方法。
Objective: To evaluate the value of single detection and combined detection of sialic acid(SA), polyamine(PA), carcinoembryonic antigen (CEA) and carbohydrate antigen 242(CA242) in the qualitative diagnosis of colorectal cancer. Methods: Serum levels of SA、PA、CEA、CA242 of 70 cases of colorectal cancer and 68 healthy adults were detected with HP%M high performance liquid chromatography, HP1040A fluorescence detector or enzyme linked immunoabsorbent assay. Sensibility, specificity, positive predictive rate, negative predictive rate, and total efficiency of single detection or combined detection of 4 TMs were calculated respectively.Results: Circulating TMs raised significantly in patients with colorectal cancer, CA242 detection had the highest availability, combined detection of SA+PA+CA242 increased sensibility of 100%, but the specificity was only 63.46%. Conclusion: Four TMs are all valuable in diagnosis of colorectal cancer. Combined detection increases diagnosis sensibility and is a good choice in population screen of colorectal cancer.
出处
《山东医科大学学报》
2000年第1期23-25,共3页
Acta Academiae Medicinae Shandong
关键词
大肠癌
定性诊断
肿瘤标记物
Colonic neoplasms
Rectal neoplasms
Sialic acids
Polyamine
Carcinoembryonic antigen
Carbohydrate antigen 242
