摘要
目的 探讨心包液肿瘤标记物检测对癌性心包积液的诊断价值。方法 采用放免法，测定经临床确诊的１７ 例转移性癌性心包积液和１５ 例良性心包积液中ＣＥＡ、ＣＡ１９９ 、ＣＡ５０含量，并予分析。结果 癌性心包液中ＣＥＡ、ＣＡ１９９ 、ＣＡ５０ 含量较良性心包液显著增高。各标记物在癌性心包液增高的阳性率均为７６－４７ ％ ，特异性为９６－８８ ％ 。ＣＥＡ 加ＣＡ１９９ 或ＣＡ５０ 联检，单项阳性率提高为８８－２４％ ，但特异性降为９３－７５ ％ 。若上述联检中多项标记物均阳性，对癌性心包液诊断的特异性可达１００％ ，但敏感性降为６４－７１％ 。结论 心包液ＣＥＡ、ＣＡ１９９ 、ＣＡ５０ 检测，可作为癌性心包积液诊断的重要依据。
Objective\ To study the diagnostic value of tumor marker assay in carcinopericardial effusion. Methods\ The pericardial fluid CEA,CA 19-9 ,CA 50 levels of 17 cases of metastatic malignant pericardial effusion and 15 cases of benign pericardial effusion were measured by radioimmunoassay.All parameters were analysed. Results\ The levels of CEA, CA 19-9 ,CA 50 in malignant pericardial effusion were significantly higher than those in benign one. The diagnostic positive rate and the specificity of each tumor marker was 76 47% and 96 88% respectively. In CEA combining with CA 19 9 or CA 50 assay, the positive rate of single tumor marker could be raised to 88 24% but the specificity lowered to 93 75%. When many tumor markers were all positive in above the combination assay,the specificity could be reached to 100% but the positive rate lowered to 64 71%. Conclusion The levels of pericardial fluid CEA, CA 19 9 ,CA 50 are important diagnostic parameters for carcinopericardial effusion.
出处
《安徽医科大学学报》
CAS
1999年第5期348-350,共3页
Acta Universitatis Medicinalis Anhui
关键词
心包液肿瘤
心包积液
癌性
诊断
tumor markers, biological
pericardial effusion
radioimmunoassay
heart neoplasms/diag
