摘要
目的总结我院近3年来慢性肾脏病患者肾脏病理类型以及不同年龄段肾脏疾病的构成比，分析慢性肾脏病分期、临床分型与病理分型之间的关系。方法收集2009年1月～2011年12月在我科行肾活检的慢性肾脏病患者2289例，对其性别、年龄、病理类型、临床分型、CKD分期等进行回顾性分析。结果（1）2289例患者平均年龄（46．6±25．7）岁，男女比例1．22：1；（2）原发性肾小球疾病占68．3％，IgA肾病最常见（占40．3％）；继发性’肾脏疾病占31．4％，狼疮性。肾炎发病率最高（28．4％），其次是糖尿病肾病（19．7％）；（3）年龄〈18岁组患者以。肾小球轻微病变最为多见（30．4％），年龄〉60岁的老年患者中以膜性肾病和糖尿病肾损害最常见；（4）慢性肾炎综合征是最常见的临床类型（37．9％）。结论慢性肾脏病好发于中青年，不同年龄段患者肾脏疾病的病理分型明显不同。原发性。肾病中IgA肾病最常见，继发性肾脏疾病以狼疮性肾炎最多见。导致慢性肾功能不全最常见的病理类型为局灶节段性肾小球硬化、IgA肾病以及糖尿病肾病。最常见的临床类型为慢性肾炎综合征和肾病综合征。
Objective To summarize the renal pathological types of chronic kidney disease （CKD） in Chongqing within the recent 3 years and to investigate the most common types in patients with different age period. In the mean time, to study the relationships among chronic kidney disease stage, clini- cal classification and pathological type. Methods Each of 2289 patients from Daping hospital between January 2009 and December 2011 received renal biopsy. Clinical data including sex, age, pathology type, clinical classification and CKD stage were retrospectively analysed. Results Of 2289 patients, the average age was 46.6 -＋ 25.7 years old（ range 2 - 83 ） and male to female ratio was 1.22： 1. The proportion of pri- mary glomerular diseases（PGD） was 68.3% ,and IgA nephropathy（IgAN） was the most common patho- logical type （40.3% of PGD）. Secondary glomerularnephritis （SGN） accounted for 31.4 % in all sub- jects. The most frequent subtype of SGN was lupusnephritis （ 28.4% ）, followed by diabetic nephropathy （ 19.7% ）. Glomerular minor lesion was prevalent in patients under 18 years old. The most common pathological types of patients over 60 years old were membraneous nephropathy and diabetic nephropathy. The most frequent clinical pattern was chronic nephritic syndrome（CNS） （37.9%）. Conclusion The patho- logical types of CKD in different age period are significantly different. In Chongqing,youth is the predilec- tion population of CKD. IgAN is the most frequent pathological type of PGD, and the most frequent subtype of SGN is lupusnephritis. FSGS, IgA nephropathy and diabetic nephropathy are the common pathological types which tend to cause chronic renal insufficiency, and the most frequent clinical pwttems were CNS and NS.
出处
《临床内科杂志》
CAS
2012年第10期686-689,共4页
Journal of Clinical Internal Medicine
关键词
病理分型
原发性肾小球疾病
继发性肾脏疾病
CKD分期
Renal pathological type
Primary glomerular diseases
Secondary glomerularne- phritis
CKD stage
