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广东汉族人群EVI5基因及LDLRAP1基因单核苷酸多态性与冠心病的相关性 被引量：1

The correlation between the polymorphisms of EVI5 gene and LDLRAP1 gene and coronary heart disease in the Guangdong Han population
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摘要 目的通过对广东地区冠心病(CHD)患者和非冠心病个体EVI5基因(rs7515577)及LDLRAP1基因(rs12027135)单核苷酸多态性(single nucletide polymorphism,SNP)的研究,分析其在CHD患者和非CHD个体中的分布情况,以及与CHD的相关性。方法选取经冠状动脉造影证实为CHD的患者143例,另选经冠状动脉造影证实无CHD的对照组79例,分别提取基因组DNA模板,采取聚合酶链反应(polymerase chain reaction,PCR)方法分析EVI5基因rs7515577位点和LDLRAP1基因rs12027135位点的SNP,并用基因测序法验证结果。结果中国广东地区CHD患者和非CHD的对照组在EVI5基因rs7515577位点C/A及LDLRAP1基因rs12027135位点T/A的等位基因频率、基因型频率分布差异无统计学意义(P>0.05)。结论 EVI5基因rs7515577及LDLRAP1基因rs12027135的多态性与CHD的发病无相关性。 Objective To investigate the distributions of the known SNPs of EVI5 and LDLRAP1 genes in Chinese patients with coronary heart disease （CHD） and non- CHD people in Guangdong area by PCR, and to analyze the correlations between these SNPs and CHD. Methods Blood samples from 143 cases of CHD diagnosed by coronary angiogaphy and 79 cases of non - CHD were collected. Genomic DNA was amplified by PCR and verified by DNA sequencing. Results There was no significant difference in allele or genotype frequency between the CHD and non - CHD indi- vidtrals （P 〉 0. 05 ）. Conclusion The rs7515577 polymorphism of the EVI5 gene or the rs12027135 polymorphism of the LDLRAP1 gene is not correlated with CHD.
作者 张源源 徐琳 邱健 莫小阳
机构地区 广州军区广州总医院干部病房一科 广州军区广州总医院心血管内科 晓庄学院生命科学学院蛋白质化学与发育生物学教育部重点实验室心脏发育研究中心
出处 《广东医学》 CAS CSCD 北大核心 2012年第22期3403-3405,共3页 Guangdong Medical Journal
基金 中国博士后科学基金特别资助项目(编号:201003745) 中国博士后科学基金一等资助项目(编号:20080440215) 广东省科技计划项目(编号:2009B011000018 2005B30601016) 广东省自然科学基金资助项目(编号:2157000068 8151051501000062) 广州市科技计划项目(编号:2009J1-c491)
关键词 冠心病 EVI5 LDLRAP1 单核苷酸多态性 coronary heart disease EVI5 LDLRAP1 SNP
分类号 R394 [医药卫生—医学遗传学]
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参考文献10

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二级参考文献12

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广东医学
2012年 第22期

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