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滤泡辅助性T细胞的主要特性及其活化的信号转导途径 被引量：2

Functions and regulation of follicular helper T cells and their relationships with diseases
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摘要 滤泡辅助性T细胞能够迁移到淋巴滤泡,参与促进生发中心的形成、维持,浆细胞(长寿的和短寿的)和记忆B细胞的产生和抗体类别转换,在辅助B淋巴细胞产生抗体中起着重要作用,是近年来发现的一种新CD4+辅助性T细胞亚群。本文将重点围绕目前综述涉及不多的信号通路调控,综述滤泡辅助性T细胞的发育分化、主要特性及与疾病的关系。 T follicular helper cells（Tfh） can migrate to lymphoid nodule and participate in promoting the formation and maintenance of germinal center,generating plasma B cells（long term and short term） and memory B cells,as well as class switching of antibody.Tfh plays an important role in helping lymph B cells produce antibody and is a recently discovered new subset of CD4＋ T helper cells.This review emphasizes the signaling pathway of T follicular helper cells and covers the differentiation,significance and their relationships with diseases.
作者 杨子晨 王康 刘超 张志仁
机构地区 第三军医大学学员旅 第三军医大学基础部全军免疫学研究所
出处 《免疫学杂志》 CAS CSCD 北大核心 2012年第12期1086-1089,共4页 Immunological Journal
关键词 滤泡辅助性T细胞 体液免疫 CXCR5 BCL-6 抗体产生 T follicular helper cells Humoral immunity CXCR5 BCL-6 Antibody production
分类号 R392 [医药卫生—免疫学]
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参考文献20

  • 1Vinuesa CG, Tangye SG, Moser B, et al. Follicular B helperT cells in antibody responses and autoimmunity [J]. Nat RevImmunol, 2005,5(11): 853-865.
  • 2Kerfoot SM, Yaari G, Patel JR, et al. Germinal center B celland T follicular helper cell development initiates in theinterfollicular zone[J]. Immunity, 2011,34(6): 947-960.
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二级参考文献54

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  • 10Nurieva RI, Chung Y, Hwang D, et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages [J]. Immunity, 2008, 29(1): 138-149.

共引文献10

同被引文献17

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免疫学杂志
2012年 第12期

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