摘要
目的探讨氨氯地平联合瑞舒伐他汀应用对高血压患者颈动脉内膜中层厚度的影响。方法将2009年1月～2011年5月收治的原发性高血压患者100例随机分为试验组与对照组各50例。对照组使用氨氯地平5mg/d,试验组氨氯地平5mg/d+瑞舒伐他汀10mg/晚,治疗12个月后比较两组的颈动脉内膜中层厚度、血压及血脂水平。结果试验组治疗12个月后颈动脉内膜中层厚度、收缩压水平以及血脂水平均有下降,与对照组相比差异有统计学意义(P<0.05)。结论氨氯地平与瑞舒伐他汀联合应用可延缓高血压患者颈动脉硬化的进程。
Objective To investigate the effect of amlodipine combined with rosuvastatin on carotid intima-media thickness in patients with hypertension. Methods During period of January 2009 to May 2011, 100 patients with essential hyperten- sion were randomly divided into experimental group （n = 50） and control group （n = 50）. The control group were given am- lodipine 5 mg per day, the experimental group were given amlodipine 5 mg per day and rosuvastatin 10 mg per night. Carotid intima-media thickness, blood pressure and lipid levels were compared in two groups after 12 months. Results Carotid intima-media thickness, systolic blood pressure and lipid levels were decreased in experimental group after 12 months＇ treatment. It was statistically significant compared with the control group （P 〈 0.05）. Conclusion Amlodipine combined with rosuvastatin may delay the process of carotid atherosclerosis in hypertensive patients.
出处
《中国当代医药》
2012年第31期75-76,共2页
China Modern Medicine
