摘要
目的观察黑木耳多糖对幼年雄性大鼠性功能的影响及其药理作用。方法将雄性大鼠40只随机分为空白对照组、多糖低剂量组、多糖高剂量组和木耳组,连续给药30d,测定血清中睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)及血清和阴茎组织中NO水平,检测精子的计数、活动度、畸形率等指标。结果高剂量组和木耳组的FSH明显低于对照组(P均<0.01),高剂量组的T明显低于对照组(P<0.05)。高剂量组和木耳组血清中NO明显低于对照组(P均<0.05),木耳组的阴茎组织中的NO明显低于对照组(P均<0.05)。高剂量组和木耳组附睾精子密度、良好精子的比例明显下降(P均<0.05)。结论黑木耳多糖可降低大鼠的睾丸功能、精子质量,影响青春期大鼠生殖器官的发育,对雄性大鼠的性功能有一定影响。
Objective It is to observe the influence and pharmacological effect of black fungus polysaccharide on sexual function of childhood male rats.Methods Forty male Wister rats were randomly divided into control group,low dose of polysaccharides group,high dose of polysaccharides group and fungus group and were given drugs for 30 days.The levels of testosterone（T）,luteinizing hormone（LH）,follicle-stimulating hormone（FSH） in serum and NO in serum and penile tissue were determined;and sperm count,activity and deformity rate were detected.Results FSH of high dose group and fungus group were significantly lower than that of control group（P0.01）.T of high dose group was significantly lower than that of control group（P0.05）.NO in serum of high dose group and fungus group were significantly lower than that of control group（P0.05）.NO in penile tissue of high dose group were significantly lower than that of control group（P0.05）.Epididymal sperm density and good sperm ratio of high dose group and fungus group were significantly lower than that of control group（P0.05）.Conclusion Black fungus polysaccharide can reduce the testicular function and sperm quality of rat,affect the development of reproductive organ and sexual function of childhood rat.
出处
《现代中西医结合杂志》
CAS
2012年第33期3671-3672,3675,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
山东省医药卫生科技发展计划项目(保健项目)(2009-16)
关键词
黑木耳多糖
睾酮
NO
雄性大鼠
black fungus polysaccharide
testosterone
NO
male rats
