摘要
慢性疼痛是指在伤害性刺激消退后，持续存在的，伴随不同程度的恐惧、焦虑等负面情绪的疾病，严重降低了患者的生活质量。疼痛机理涉及多个方面，其中中枢突触重塑成为近年来的研究热点。脑和脊髓水平的谷氨酸能突触和树突棘重塑，是突触重塑在疼痛形成发展机理中的的两大主要方式。本文将对突触重塑在慢性疼痛机理研究的进展进行详细阐明，以为疼痛机理及治疗的基础及临床研究，提供更为广泛的视野。
Chronic pain is a perseverative disease accompanied with sev6ral negative emotions, such as scare and anxiety, after extinction of the noxious stimulation, which decreases significantly the quality of patients＇ lives. Synaptic plasticity in the CNS has been the research hotpot in recent years, though the mechanisms of chronic pain are complex. There are two fundamental forms of synaptic plasticity, plasticity of glutamatergic synapse and dentritic spine remodeling, in the levels of spinal cord and brain. The advances in the studies of the mechanisms of synaptic plasticity in the chronic pain are reviewed to provide broader perspectives for the basal and clinic studies involved in pain.
出处
《实用疼痛学杂志》
2012年第4期295-299,共5页
Pain Clinic Journal
基金
国家自然科学基金项目
关键词
疼痛
慢性病
痛觉过敏
中枢神经系统
突触
神经元可塑性
谷氨
酸
树突棘
Pain
Chronic disease
Hyperalgesia
Central nervous system
Synapses
Neuronal plasticity
Glutamic acid
Dentritic spine
