摘要
目的观察胸腺肽α1联合化疗对非小细胞肺癌患者细胞免疫功能的影响。方法 76例非小细胞肺癌患者分为两组,对照组(n=38)仅采用吉西他滨+顺铂方案(GP方案)化疗,观察组(n=38)在对照组治疗基础上加用胸腺肽α1治疗。观察两组疗效及外周血T细胞亚群变化情况。结果观察组治疗总有效率(52.6%)明显高于对照组(36.8%)(P<0.05);观察组治疗后CD3+、CD4+、CD4+/CD8+明显高于治疗前和对照组治疗后(P<0.05),而治疗后CD8+明显降低(P<0.05)。结论胸腺肽α1联合化疗治疗非小细胞肺癌患者可明显增强机体的细胞免疫功能,提高临床疗效。
Objective To observe the influence of thymosin alpha 1 combined with chemotherapy on cellular immune function in patients with non-small cell lung cancer. Methods 76 patients with non-small cell lung cancer were divided into two groups, the control group （ n = 38 ） was only treated with gemcitabine ＋ cisplatin chemotherapy （ GP regimen）, and the observation group （ n = 38） was trea- ted with thymosin alphal on the base of control group. The therapeutic effect and change of T lymphocyte subsets in peripheral blood of two groups were observed. Results The total effective rate of observation group （52. 6% ） was significantly higher than that of control group （ 36. 8% ） （ P 〈 0. 05 ）. The levels of CD3＋ , CD4＋ , CD4＋/CD8＋ in observation group after treatment were significantly higher than those of before treatment and control group after treatment （ P 〈 0. 05 ）, but the levels of CDs＋ after treatment were significantly lower （ P 〈 0. 05 ）. Discussion The treatment of thymnsin alpha 1 combined with chemotherapy for patients with non-small cell lung cancer could significantly enhance the body＇s immune function, and improve the clinical curative effect.
出处
《临床肺科杂志》
2012年第12期2245-2246,共2页
Journal of Clinical Pulmonary Medicine
关键词
胸腺肽
非小细胞肺癌
细胞免疫
Thymosin
Non-small cell lung cancer
Cellular immunity
