摘要
目的 探讨外周血中CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞在结直肠癌中的变化及其临床意义。方法 采用流式细胞术检测 6 0例结直肠癌患者手术前、术后 1个月和 3个月时 ,外周血的CD4 + T细胞、CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞的比例。选取健康查体人群 10例作为对照。结果 结直肠癌患者的CD4 + T细胞与健康人群相比无差异。CD4 + CD4 5RO+ T细胞比例明显增高 ,术后有显著下降 ,DukesA、B期患者尤其明显 ;而CD4 + CD4 5RA+ T细胞比例正好相反。结论 CD4 + CD4 5RA+ T细胞和CD4 + CD4 5RO+ T细胞在肿瘤免疫中起重要作用 ,其表达同结直肠癌的分期和预后有密切关系。
Objective To investigate the alternation and significance of CD4 +CD45RA + T cells and CD4 +CD45RO + T cells in peripheral blood of colorectal cancer patients. Methods The expression of CD4 + T cells, CD4 +CD45RA + T cells and CD4 +CD45RO + T cells in peripheral blood of 60 colorectal cancer patients were detected with flow cytometry pre operatively and 1, 3 months post operatively, compared with those of 10 healthy persons. Results CD4 + T cells expression of colorectal cancer patients was the same as the healthy persons. The proportion of CD4 +CD45RO + T cells of colorectal cancer patients was higher, which descended post operatively, especially in Dukes A and B patients, while CD4 +CD45RA + T cells showed the opposite findings. Conclusion CD4 +CD45RA + T cells and CD4 +CD45RO + T cells, playing an important immune effect in colorectal cancer patients, is closely related to stage and prognosis. [
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2003年第4期362-364,共3页
Chinese Journal of Oncology
