摘要
目的 探讨创伤对麻醉耐受性的影响及与血浆 β 内啡肽改变的关系。 方法 新西兰兔 2 0只随机分为对照组和创伤组。连续监测MAP、CVP、PETCO2 和ECG ,测定对照组七氟醚MAC ;创伤组兔一侧下肢股骨粉碎骨折合并软组织损伤 ,测量七氟醚MAC ,两组动物分别于下列时间点测定 内啡肽浓度 :实验准备前、实验准备后、实验准备后 30min和 6 0min或创伤后 5min和 30min、MAC测定点 (即夹尾呈阳性反应点和夹尾呈阴性反应点 )。结果 对照组和创伤组七氟醚MAC分别为 2 .2 %± 0 .2 %和 1.7%± 0 .2 % ,创伤后 β 内啡肽浓度较对照组显著升高。创伤后 5min和 30min 内啡肽浓度较对照组升高 44 %和 5 2 % ;结论 新西兰兔七氟醚MAC为 2 .2 %± 0 .2 % ,创伤可明显降低吸入麻醉药MAC ,与创伤引起体内β
Objective In order to explore the effects of trauma on MAC and its mechanism, the changes in MAC of sevoflurane and plasma β endorphin were investigated in state of trauma. Methods Twenty New Zealand rabbits were randomly divided into control group and trauma group. MAP,CVP, P ET CO 2 and ECG were monitored continuously. The MAC of sevoflurane was measured in the two groups. In trauma group, the left femur of rabbits was fractured combined with parenchyma damage.Plasma β endorphin concentration was assaied at various times in two groups. Results MAC of sevoflurane was 2 2%±0 2% in control group and 1 7%±0 2% in trauma group. Trauma induced increase of plasma β endorphin concentration significantly 5min and 30min after trauma,β endorphin concentration increased by 44% and 52% in trauma group, respectively. Conclusions MAC of sevoflurane in rabbits is 2 2%±0 2%.Trauma can reduce MAC of inhalational anesthetic significantly. The endogenous β endorphin releasing enormously induced with trauma may be one of the mechanisms to decrease MAC of inhalational anesthetics.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第5期295-297,共3页
Chinese Journal of Anesthesiology
基金
军队"九五"基金!课题项目 96 0 112
关键词
创伤
Β内啡肽
七氟醚
最低肺泡浓度
麻醉
Wounds and injuries
beta Endorphin
Sevoflurane
Minimum alveolar concentration
