摘要
目的观察并比较布托啡诺硬膜外与静脉两种给药途径用于剖宫产手术的镇痛效果。方法40例择期剖宫产手术的患者,随机分为2组:硬膜外组和静脉组。两组患者关腹时,分别从硬膜外和静脉给予布托啡诺1mg,给药后24h内进行监测,记录平均动脉压(MAP)、心率(HR)、呼吸(RR)、血氧饱和度(SpO2)、术后视觉模拟评分(VAS)、舒适度(BCS)、镇静(Ramesay)评分及不良反应。结果两组VAS评分在术后2、4、8h差异无统计学意义,术后12、24h,静脉组的VAS评分显著高于硬膜外组(P<0.05),两组不良反应差异无统计学意义(P>0.05)。结论硬膜外给予布托啡诺镇痛效果优于静脉给药,且镇痛时间比静脉组延长,值得临床推广。
Objective To observe and compare the postoperative analgesia effects of butorphanol by intravenous and epidural administration in caesarean section.Methods 40 cases of patients undergoing selective caesarean section were randomly divided into two groups：intravenous butorphanol group and epidural butorphanol group.The two groups were given 1 mg butorphanol intravenously or epidurally at the same time when abdominal closure.The MAP,HR,RR,SpO2,VAS,BCS,Ramesay score,and adverse effect in first 24 hours were monitored.Results There was no statistical difference of VAS at 2 hour,4 hour,and 8 hour after operation between two groups,while VAS in intravenous group were obviously higher than that in epidural butorphanol group（P0.05）at 12 hour,24 hour,and there was no obvious difference of adverse effects in two groups（P0.05）.Conclusion Epidural administration can provide better postoperative analgesia than intravenous for caesarean section,with longer analgesia time,and it is worth extending in clinical anesthesia.
出处
《实用药物与临床》
CAS
2010年第2期103-104,共2页
Practical Pharmacy and Clinical Remedies
基金
辽宁省教育厅科技攻关项目(05L436)
关键词
布托啡诺
术后镇痛
硬膜外
静脉
Butorphanol
Postoperative analgesia
Epidural
Intravenous
