摘要
目的 观察全麻病人吸入地氟醚后血氟、尿氟、血肌酐 (Cr)及尿素氮 (BUN)的变化。方法 选择择期手术ASAI级病人 2 0例 ,术前肝肾功能检查均正常。用芬太尼、异丙酚、维库溴铵静注诱导 ,插管后吸入地氟醚。于吸入地氟醚前、术毕、术后 4h、2 4h、72h、144h采动脉血和静脉血 ,同时留置尿液 ,用氟离子选择电极法测定血氟、尿氟的含量。结果 地氟醚的麻醉时间为 (4 .36± 0 .39)h ,吸入浓度为 (1.6 5± 0 .16 )MAC ,吸入总量为 (7.19± 0 .82 )MAC h ,病人术毕、术后 4h、2 4h、72h、144h的血氟离子浓度及尿氟离子排泄率与吸入前相比均无显著差异 ,血Cr及BUN含量在各个时间点亦无明显变化。结论 地氟醚麻醉后对血氟、尿氟均无明显影响 。
Objective To observe the changes of serum and urine fluoride,Cr and BUN in patients with desflurane inhalation.Methods Twenty patients ASA class I, scheduled for selective surgery, were selected. The anesthesia was induced with fentanyl, propofol and vecuronium and was maintained with inhaling desflurane. Arterial and venous blood samples were drawn before desflurane inhalation, at the end of operation, 4 h, 24 h, 72 h and 144 h after operation. Urine were collected at the same time. Serum and urine fluoride levels were detected with fluoride ion electrode methods.Results Inhalation of desflurane was maintained for (4.36±0.39)h at concentration of (1.65±0.16)MAC, with the total inhalation amount of MAC (7.19±0.82)MAC h. No significant changes occurred in either serum fluoride concentration or urine fluoride excretion rate. Cr and BUN contents showed unsignificant changes during whole procedures.Conclusions Desflurane inhalation has no effect on serum and urine fluoride concentrations and renal function.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第5期274-276,共3页
Chinese Journal of Anesthesiology
关键词
药代动力学
地氟醚
全身麻醉
血氟
尿氟
Pharmacodynamics
Desflurane
Fluoride ion
Renal function
