摘要
小鼠腹腔注射NaF溶液两周后，免疫毒理实验结果表明：染毒小鼠体重下降；血氟、尿氟升高，骨氟在正常范围内；胸腺及脾脏脏器系数低剂量组增高，高剂量组降低；外周血淋巴细胞转化率及ANAE阳性率降低，抗体形成细胞数量减少，血清γ-球蛋白百分比及含量降低。提示NaF对小鼠的细胞免疫和体液免疫功能均有一定的损害。
Intraperitoneal injection with NaF solution on mice was carried out for two weeks. The resultsof immune tests showed as follows: For administrated group, body weight decreased, serum andurine fluoride increased, and fluoride in bone was within the normal range. At the same time immune indexes such as lymphocyte ANAE (+) rate and trans formation rate,count of plasmacyte,percentage and content of γ-globulin in serum decreased. It indicated that NaF had adverse effectsin some extent on the function of mice's cellular and humoral immunity
出处
《工业卫生与职业病》
CAS
CSCD
1997年第6期326-328,共3页
Industrial Health and Occupational Diseases
基金
冶金工业部有偿基金
关键词
氟化钠
免疫功能
Sodium fluoride
Mice
Immune function
