摘要
目的:考察紫冰霜对小鼠实验性烫伤的治疗作用和对皮肤创面愈合的促进作用。方法:建立小鼠背部Ⅱ度烫伤模型,观察紫冰霜对烫伤的治疗效果;建立小鼠背部双侧圆形创伤模型,观察紫冰霜对创伤创面愈合时间的影响。结果:在小鼠Ⅱ度烫伤模型中,与模型组比较,紫冰霜组可明显缩短愈合时间、减小烫伤面积(P<0.01)。在小鼠创伤实验中,在创伤后5～15d,紫冰霜组小鼠创面愈合面积明显高于自身对照和模型组(P<0.01)。结论:紫冰霜具有治疗实验动物烫伤和促进创伤创面愈合的作用。
OBJECTIVE To investigate the effect of Zibing cream on experimental scald and skin wound healing in mice.METHODS Ⅱ degree scald model and bilateral round wounds were made on the backs of mice respectively.The effect of Zibing cream on skin wound was evaluated through determining the closure time and contracting ability of the skin wound.RESULTS Compared with the model group,Zibing cream could significantly reduce the healing time and the scald area in mice（P0.01）,and the mice wound healing area was significantly higher than the self-control and model group on the 5 th to 15 th days after wounding（P0.01）.CONCLUSION Zibing cream has the therapeutic effect on scald and wound healing in experimental animal.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第21期1713-1715,共3页
Chinese Journal of Hospital Pharmacy
基金
陕西省科技研究发展攻关项目(编号:2004K18-G9)
关键词
紫冰霜
烫伤
创伤
小鼠
Zibing cream
scald
wound healing
mice
