摘要
随着基因组学、生物化学、分子生物学及多肽合成等科学技术的发展,蛋白质及多肽药物已成为跨国医药企业竞相争夺未来生物医药领域的一个制高点。但是蛋白质类药物的临床应用受到了其理化及生物特性的种种限制,为了改善治疗效果,近年来聚合物修饰的蛋白质类药物有了长足的发展。本文着重回顾了蛋白质类药物聚乙二醇修饰的发展和现状,以及由此获得的优点和局限性;同时介绍了其它新型生物相容性聚合物蛋白质类药物修饰的最新研究进展,探讨了蛋白质类药物的"后聚乙二醇修饰"时代的可能方向和应用前景。
With the development of science and technology in genomics, biochemistry, molecular biology and peptide synthesis, protein drugs are becoming very important ones and widely used in clinical. However, the low stability, fast clearance and immunogenicity of protein drugs become the major hindrances in their efficient clinical applications. Thus, the polymer-protein conjugation becomes a more and more vital method to improve the efficiency of protein drug in clinic. In this paper, we discussed the development of the application of poly （ethylene glycol）（PEG） in the polymer-protein conjugation technology in recent years, and the advantages and limitations of this technology. And we also discussed the recent advance in other new polymeric materials and methods for the polymer-protein conjugation.
出处
《高分子通报》
CAS
CSCD
北大核心
2012年第11期18-23,共6页
Polymer Bulletin
基金
国家自然科学基金(20974095
20936005
21174127)
