摘要
评价有机锗 (Ge -13 2 )对苯中毒小鼠白细胞降低的治疗作用在制备动物模型的基础上 ,将符合诊断标准的动物给予鲨肝醇和不同剂量有机锗治疗。 4周后 ,对其外周白细胞总数、分类、血红蛋白骨髓及脏器系数进行检测。结果显示 :Ge-13 2对人工诱导苯中毒所致的外周白细胞降低有一定的治疗作用 ,它优于鳖肝醇 ,以 5 0 0mg/kg剂量组治疗效果最佳。提示有机锗治疗苯中毒所致的白细胞减少症比鲨肝醇更有效。
To evaluate reatmental effects of Ge-132 and Batiolum on decrease of WBC counts in bezene-exposedmice.The mice conforming to diagnotic carteria were treated by Ge-132 and Batiolum indifferent dosdage.under the base of animal model.The peripheral WBC counts,WBC classification,heatoglobin level,bone marrow cell and dorgan coefficient were checked after four weeksd.Ge-132 has hematopoiesis effect in bezene-exposed mice and is better than Bdatiolum espeilly in 500mg/kg group.Ge-132 is better than Batiolum in treating decrease of WBC in bezene-exposed mice.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2000年第5期419-420,共2页
Chinese Journal of Public Health
基金
山东省教委基金
