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基质金属蛋白酶与糖尿病血管病变 被引量：3

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摘要 糖尿病血管病变的发生发展涉及多个环节。基质金属蛋白酶 (MMPs)在细胞外基质 (ECM)动态平衡、组织重塑、修复等病理生理过程中起重要作用。糖尿病合并血管病变患者循环MMPs水平升高 ,且先于血管病变。在病变血管部位MMPs表达增加 ,提示MMPs在糖尿病血管病变的发生、发展中起重要作用。糖尿病时MMPs的改变与高血糖及胰岛素缺乏有关。
作者 郭立新 汪恕萍
机构地区 重庆医科大学附属第一医院内分泌科
出处 《国外医学（内分泌学分册）》 2000年第3期120-123,共4页 Foreign Medical Sciences(Section of Endocrinology)
基金 重庆市卫生局科研课题!编号992019
关键词 基质金属蛋白酶 抑制剂 糖尿病血管病
分类号 R587.202 [医药卫生—内分泌]
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参考文献15

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同被引文献20

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二级引证文献21

国外医学（内分泌学分册）
2000年 第3期

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