摘要
目的 研究组织蛋白酶 D(CD)的表达与膀胱移行细胞癌 (BTCC)生物学行为间的关系 ,并探讨 BTCC发生浸润转移的机制。方法 应用免疫组化 ABC法检测 33例 BTCC及 12例正常膀胱组织中 CD与碱性成纤维细胞生长因子 (b FGF)的表达。结果 CD在正常膀胱移行细胞均呈弱阳性表达 ,BTCC组肿瘤细胞的过表达率显著高于正常对照组 (P<0 .0 5 ) ,且在不同病理分级、临床分期、单发与多发、初发与复发组间均有显著性差异 (P<0 .0 5 )。 BTCC组 CD过表达与 b FGF阳性表达间有显著相关性 (P<0 .0 5 )。结论 CD与 BTCC生物学特性密切相关 ,与 b
Objective To evaluate the relationship between the expression of cathepsin D(CD)and biological behaviour of bladder transitional cell carcinoma (BTCC)and the mechanisms of invasiveness. Methods The expression of CD and bFGF was detected by standard ABC immunohistochemical technique in 33 paraffin embedded tissue specimens of BTCC. Results All normal transitional cells were weakly stained. The over expression rate of CD in BTCC group was significantly higher than in normal control group ( P <0.05). Fisher′s accurate analysis showed that over expression rate of CD in tumour cells closely correlated with different pathological grades( P <0.05), clinical stages( P <0.05),number of lesions( P <0.05)and postoperative reccurance( P <0.05). The over expression of CD and bFGF showed significant relativity in same groups of BTCC( P <0.05). Conclusion The expression of CD closely correlated with complex and variable biological characteristics of BTCC. The synergy of CD and bFGF may influence the invasiveness and metastasis of BTCC.
出处
《南京医科大学学报（自然科学版）》
CSCD
2000年第3期200-202,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
膀胱肿瘤
移行细胞癌
组织蛋白酶D
BFGF
生物学
bladder neoplasms
transitional cell carcinoma
cathepsin D
basic fibroblast growth factor
biological behaviour
human
