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Dickkopf-1与强直性脊柱炎相关性研究进展

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摘要 强直性脊柱炎（ankylosing spondylitis，As）是一种以骶髂关节及脊柱中轴关节为主要病变的慢性进行性炎症性疾病，晚期出现严重胸腰椎后凸等畸形及骶髂关节融合。骨重塑中是以新骨形成为该病的特点，但目前具体发病机制尚不清楚。
作者 郑晓娟 刘湘源
机构地区 北京大学第三医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2012年第11期778-780,共3页 Chinese Journal of Rheumatology
关键词 强直性脊柱炎 DICKKOPF-1 相关性 Wnt信号通路 成骨细胞分化 骶髂关节 新骨形成 炎症性疾病
分类号 R593.23 [医药卫生—内科学]
  • 相关文献

参考文献18

  • 1Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene, 2006, 25: 7469-7481.
  • 2Aravind L, Koonin EV. A colipase fold in the carboxy-terminal domairr of the Wnt antagonists:the Dickkopfs. Curt Biol, 1998, 8 : R477-478.
  • 3Bafico A, Liu G, Yaniv A, et al. Novel mechanism of Wnt sig-nalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol, 2001, 3: 683-686.
  • 4Li J, Sarosi I, Cattley RC, et al. Dkkl-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone, 2006, 39: 754-766.
  • 5Morvan F, Boulukos K, Clement-Lacroix P, et al. Deletion of a single allele of the Dkkl gene leads to an increase in bone formation and bone mass. J Bone Miner Res, 2006, 21: 934- 945.
  • 6Diarra D, Stolina M, Polzer K, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med, 2007, 13 : 156-163.
  • 7Uderhardt S, Diarra D, Katzenbeisser J, et al, Blockade of Dickkopf (DKK)-I induces fusion of sacroiliac joints. Ann Rheum Dis, 2010, 69: 592-597.
  • 8Kwon SR, Lim MJ, Suh CH, et al. Diekkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy. Rheumatol Int, 2012, 32: 2523-2527.
  • 9Heiland GR, Appel H, Poddubnyy D, et al. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann RheumDis, 2012, 71: 572-574.
  • 10Wang N, Morrow S, Mallon C, et al. DKK-1 levels are com- parably increased in patients with as and RA, show similar decreases with anti-TNF therapy, and are not associated with markers of bone remodeling. Ann Rheum Dis, 2008, 67 Suppl II: 129.

二级参考文献50

  • 1古洁若,张汉伟,赵丽珂,黄烽,颜光美,余得恩.基质金属蛋白酶-3在强直性脊柱炎中的作用和意义探讨[J].中国药物与临床,2004,4(4):270-276. 被引量：14
  • 2赵伟,黄烽.护骨素在强直性脊柱炎外周关节骨质破坏病理机制中的作用[J].中华风湿病学杂志,2005,9(6):329-333. 被引量：18
  • 3赵伟,黄烽.破骨细胞在强直性脊柱炎滑膜组织中的分化及其在外周关节骨质破坏病理机制中的作用[J].解放军医学杂志,2005,30(11):981-984. 被引量：8
  • 4Rudwaleit M,Listing J,Brandt J,et al.Prediction of a major clinical response (BASDAI 50) to turmour necrosis factor alpha blockers in ankylosing spondylitis.Ann Rheum Dis,2004,63:665 -670.
  • 5Haibel H,Rudwaleit M,Listing J,et al.Efficacy of adalimumab in the treatment of axial spondylarthritis without radiographically defined sacroiliitis:results of a twelve-week randomized,doubleblind,placebo-controlled trial followed by an open-label extension up to week fifty-two.Arthritis Rheum,2008,58:1981-1991.
  • 6Sieper J,Appel H,Braun J,et al.Critical appraisal of assessment of structural damage in ankylosing spondylitis:implications for treatment outcomes.Arthritis Rheum,2008,58:649-656.
  • 7Vandooren B,Cantaert T,Noordenbos T,et al.The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation.Arthritis Rheum,2008,58:718-729.
  • 8Schett G,Stolina M,Dwyer D,et al.Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis.Arthritis Rheum,2009,60:2644-2654.
  • 9Diarra D,Stolina M,Polzer K,et al.Dickkopf-1 is a master regulator of joint remodeling.Nat Med,2007,13:156-163.
  • 10Uderhardt S,Diarra D,Katzenbeisser J,et al.Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints.Ann Rheum Dis,2010,69:592-597.

共引文献21

中华风湿病学杂志
2012年 第11期

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