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癌相关成纤维细胞与口腔癌关系的研究进展

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摘要 上皮组织与间质通过复杂而精细的网络系统构成一个平衡的微生态体系，当各种因素导致恶性肿瘤发生时，原有的微生态平衡被打破，变异上皮及其邻近宿主间质会构成新的微生态体系。间质细胞与细胞外基质（extracellularmatrix，ECM）构成的肿瘤-宿主界面微环境在肿瘤的发生、发展过程中扮演着重要角色。肿瘤细胞的微环境不同于正常间质，称为“反应性间质”，表现为：ECM成分改变、微血管密度增加。
作者 李怡宁 胡济安
机构地区 浙江大学医学院附属口腔医院病理科
出处 《中华口腔医学杂志》 CAS CSCD 北大核心 2012年第11期701-703,共3页 Chinese Journal of Stomatology
基金 基金项目：国家自然科学基金（81172560） 浙江省教育厅2010年度科研计划（Y201017802）
关键词 癌相关成纤维细胞 口腔癌 微生态平衡 间质细胞 肿瘤发生 上皮组织 细胞外基质 微血管密度
分类号 R739.8 [医药卫生—肿瘤]
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参考文献44

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二级参考文献36

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  • 2宋惠云,何昕,周红梅,李胜富,付春华,龙丹.口腔癌相关成纤维细胞对人工基底膜的降解作用及其机制[J].华西口腔医学杂志,2007,25(3):223-225. 被引量：6
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中华口腔医学杂志
2012年 第11期

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