摘要
间质细胞与细胞外基质构成的肿瘤-宿主界面微环境对肿瘤细胞的生长、浸润和转移具有重要作用。其中,癌相关成纤维细胞是最重要的宿主细胞,对口腔癌的发生发展起着重要的作用,以其为靶标所进行的肿瘤间质治疗开拓了肿瘤防治新途径。下面就癌相关成纤维细胞及其来源、与口腔癌的关系和治疗作一综述。
Tumor-host interface microenvironment is composed of mesenchymal cells and extra cellular matrix components,which plays an important role in the growth,invasion and metastasis of tumor cells.The most important cell component in this environment is the cancer-associated fibroblas（tCAF）,which plays an important role in oral cancer development,and the tumor mesenchymal therapy which aims to CAF exploit a new path of tumor prevention and treatment.This article is an overview about CAF and its original,researching its relation with oral cancer and therapy.
出处
《国际口腔医学杂志》
CAS
2010年第2期178-181,185,共5页
International Journal of Stomatology
关键词
癌相关成纤维细胞
口腔癌
治疗
cancer-associated fibroblast
oral cancer
therapy
