摘要
[目的]探索MMP-2和MMP-9与口腔扁平苔藓(oral lichen planus,OLP)的发生、发展乃至癌变潜能的关系。[方法]采用免疫组化SP法检测MMP-2和MMP-9在22例OLP、11例正常口腔黏膜组织、22例白斑和22例口腔鳞癌组织表达。[结果]在正常口腔黏膜、扁平苔藓、白斑和鳞癌组织中MMP-2和MMP-9的表达依次增加。MMP-2和MMP-9在口腔扁平苔藓和白斑中的表达显著高于正常口腔黏膜(P<0.05),但在口腔扁平苔藓和白斑间的表达差异无显著性意义(P>0.05);在鳞癌中的表达显著高于其他3组(P<0.05)。[结论]MMP-2和MMP-9表达与OLP的发生、发展乃至癌变潜能有关。
[Objective] To Explore the relationshiops of MMP-2 and MMP-9 to the OLP occurrence,the development and even the canceration potential.[Methods] Immunohisto-chemistry was performed to examine expressions of MMP-2 and MMP-9 in 22 OLP,11 normal oral mucosa,22 oral leukoplakia and 22 squamous cell carcinoma.[Results] The expression of MMP-2 and MMP-9 increased in turn from normal oral mucosa to OLP,oral leukoplakia and oral squamous cell carcinoma tissues.The expression of MMP-2 and MMP-9 in OLP and oral leukoplakia was significantly higher than that in normal oral mucosa（P0.05）,there was significant difference;There was no significant difference between the positive expression of MMP-2 and MMP-9 in OLP and oral leukoplakia（P0.05）;The expression of MMP-2 and MMP-9 in squamous cell carcinoma was significantly higher than The other three groups（P0.05）,there was significant difference.[Conclusion] The expression levels of MMP-2 and MMP-9 correlate with the occurrence of oral lichen planus,development and even cancer potential,which may be useful indicator to judge the possibility of malignant change of OLP.
出处
《大连医科大学学报》
CAS
2012年第5期446-449,共4页
Journal of Dalian Medical University
