慢性阻塞性肺疾病抗氧化治疗的研究进展被引量：1

Recent progress in relationship between the oxidant / antioxidant imbalance and chronic obstructivepulmonary disease

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摘要慢性阻塞性肺疾病（COPD）是最常见的呼吸系统疾病，其确切的发病机制尚不明确，氧化／抗氧化失衡在其发病过程中发挥了重要作用。氧化损伤是COPD的重要发病机制之一。本文对近年来氧化／抗氧化失衡在COPD发病中作用机制及抗氧化治疗的研究进展作一综述。 Chronic obstructive pulmonary disease （COPD） is the most common respiratory diseases, and its exact pathogenesis is unclear. Evidence shows that oxidant / antioxidant imbalance might play an important role in the disease. Oxidative damage is one of the important pathogenesis of COPD. Recent research progress of oxidant / antioxidant imbalance pathogenesis in COPD is reviewed in this article.

作者韩书芝平芬张凤蕊

机构地区河北省人民医院呼吸科

出处《国际呼吸杂志》 2012年第21期1652-1654,共3页 International Journal of Respiration

关键词慢性阻塞性肺疾病氧化抗氧化失衡抗氧化治疗 Chronic obstructive pulmonary disease Oxidant/antioxidant imbalance Antioxidant treatment

分类号 R563.9 [医药卫生—呼吸系统]

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参考文献16

1Cote CG. Surrogates of mortality in chronic obstructive pulmonary disease. Am J Med,2006,119(10 Suppl 1) :54-62.
2Zhong N, Wang C, Yao W, et al. Prevalence of chronic obstructive pulmonary disease in China: a large, population- based survey. Am J Respir Crit Care Med, 2007, 176: 753- 760.
3MacNee W. Oxidants/antioxidants and chronic obstructive pulmonary disease: pathogenesis to therapy. Novartis Found Symp, 2001,234 - 169-185 ; discussion 185-188.
4Zang LY, Stone K, Pryor WA. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med, 1995,19: 161-167.
5Yoshida T, Tuder RM. Pathobiology of cigarette smoke induced chronic obstructive pulmonary disease. Physiol Rev, 2007,87: 1047-1082.
6Hoshino S, Yoshida M, Inoue K, et al. Cigarette smoke extract induces endothelial cell injury via JNK pathway. Biochem Biophys Res Commun, 2005,329:58-63.
7Cavalcante AG, de Bruin PF. The role of oxidative stress in COPD: current concepts and perspectives. J Bras Pneumol, 2009,35:1227-1237.
8张智健.N-乙酰半胱氨酸在呼吸系统疾病中的应用[J].中国药物应用与监测,2007,4(2):20-22. 被引量：29
9Jimenez LA, Thompson J, Brown DA, et al. Activation of NF-kappaB by PM (10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicol Appl Pharmacol, 2000,166 : 101-110.
10Zheng JP, Kang J, Huang SG,et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet, 2008,371: 2013-2018.

二级参考文献16

1[1]Kasielski M,Nowak D.Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease[J].Respir Med,2001,95(6):448.
2[2]Szkudlarek U,Zdziechowski A,Wit kowski K,et al.Effect of inhaled N-acetylcysteine on hydrogen peroxide exhalation in healthy subjects[J].Pulm Pharmacol Ther,2004,17(3):155.
3[3]Macnee W.Oxidants/antioxidants and chronic obstructive pulmonary disease:pathogenesis to therapy[J].Novartis Found Symp,2001,234:169.
4[4]Antonicelli F,Parmentier M,Drost EM,et al.N-acetylcysteine inhibits oxidant-mediated interleukin-8 expression and NF-KappaB nuclear binding in alveolar epithelial cells[J].Free Radic Biol Med,2002,32(6):492.
5[5]Cavarra E,Lucattelli M,Gambelli F,et al.Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress[J].Am J Physiol Lung Cell Mol Physiol,2001,281 (2):L412.
6[6]Metnitz PG,Bartens C,Fischer M,et al.Antioxidant status in patients with acute respiratory distress syndrome[J].Intensive Care Med,1999,25 (2):180.
7[7]Laurent T,Markert M,Feihl F,et al.Oxidant-antioxidant balance in granulocytes during ARDS.Effect of N-cetylcysteine[J].Chest,1996,109(1):163.
8[8]Domenighetti G,Quattropani C,Schaller MD,et al.Therapeutic use of N-acetylcysteine in acute lung diseases[J].Rev Mal Respir,1999,16(1):29.
9马学军,舒跃龙,译.精编分子生物学实验指南.第4版.北京:科学出版社,2005.20-22.
10Borek C.Antioxidant health effects of aged garlic extract.J Nutr,2001,131 (3s):1010S-1015S.