摘要
目的评价盐酸帕洛诺司琼预防高度催吐危险的化疗方案所致恶心、呕吐的疗效和安全性。方法将符合纳入标准的恶性肿瘤患者随机分入AB组和BA组,于化疗前30 min缓慢静推盐酸帕洛诺司琼或盐酸托烷司琼。观察化疗后5 d内恶心、呕吐情况,以及不良反应。结果共纳入24例患者,可评价18例。2种药物对恶心、急性呕吐的完全控制率及有效控制率,以及对迟发性呕吐的完全控制率比较,无显著差异,而盐酸帕洛诺司琼对迟发性呕吐的有效控制率显著高于盐酸托烷司琼。2种药物不良反应较少且程度较轻。结论盐酸帕洛诺司琼预防高度催吐危险的化疗方案所致恶心和急性呕吐的疗效与盐酸托烷司琼相当,但预防迟发性呕吐的疗效优于盐酸托烷司琼,且不良反应发生率低、程度轻。
Objective To assess the efficacy and safety of palonosetron for preventing nause- a and vomiting caused by high emetic risk chemotherapy. Methods Malignant patients who were accord with the standard were assigned to groups AB and BA randomly to receive a single dose of palonosetron or tropisetron 30 min before chemotherapy. The nausea and vomiting episodes and ad- verse effects within 5 days after chemotherapy were observed. Results A total of 24 patients were enrolled and only 18 patients could be evaluated. The complete control rates and efficacy control rates of acute nausea, delayed nausea, acute vomiting, and the complete control rate of delayed vomiting showed no significant differences. The efficacy control rate of delayed vomiting with palonosetron was obviously higher than that with tropisetron. The adverse reactions of the two drugs were fewer and mild without statistic difference. Conclusion For high emetic risk chemotherapy, palonosetron is similar to tropisetron for preventing nausea and acute vomiting. But it is superior to tropisetron for preventing delayed vomiting with fewer and mild side effects.
出处
《实用临床医药杂志》
CAS
2012年第19期43-45,51,共4页
Journal of Clinical Medicine in Practice
关键词
帕洛诺司琼
托烷司琼
化疗
恶心
呕吐
palonosetron
tropisetron
chemotherapy
nausea
vomiting
