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父源性染色体异常胚胎植入前遗传学诊断的最新研究进展 被引量:5

Progress of Preimplantation Genetic Diagnosis of Embryos Derived from Paternal Sex Chromosome Abnormality
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摘要 染色体异常是导致男性不育的一个重要原因。不同类型染色体异常的生殖细胞进行减数分裂时形成不同类型的配子,且各种异常配子所比例的实际值与理论值不相符。另外,正常胚胎率与正常配子率也不一致。本文对染色体结构异常(相互易位、罗伯逊易位、倒位、染色体复杂性重组)和数目异常(性染色体数目异常、常染色体数目异常)男性的正常精子率以及正常胚胎率进行综述。 Chromosomal abnormality is an important reason for male infertility. Germ cell with different kinds of chromosomal abnormality can form defferent gemete accounting for different proportions.And the pratical rates of abnormal gemete are different from the theoretical.The objective of this article is to summarize the normal rates of gemete and embryo of those male with chromosomal structural abnormality, for example reciprocal translocation, robertsonian translocation, inversion, complex chromosome rearrangements, and chromosomal nu- merical abnormality, for example sex chromosomes numerical abnormality and autosome numerical abnormality.
出处 《生殖与避孕》 CAS CSCD 2012年第11期765-770,共6页 Reproduction and Contraception
关键词 染色体异常 体外受精 胚胎植入前遗传学诊断(PGD) 荧光原位杂交技术(FISH) chromosomal abnormality in vitro fertilization preimplantation genetic diagnosis(PGD) fluorescence in situ hybridization(FISH)
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