摘要
目的综述锶(Sr)的成骨效应及其在骨科中应用的研究进展。方法广泛查阅近年国内外有关Sr成骨效应及其在骨科中应用的文献,并对其进行分析。结果体内外研究表明Sr具有促进骨生成和抑制骨重吸收的双重作用。临床上,Sr被应用于骨质疏松的治疗,组织工程生物材料的复合及骨肿瘤、骨转移瘤的治疗。结论 Sr是骨组织工程替代材料的重要复合元素之一,能增强骨替代材料的机械性能和生物学性能,在骨组织工程中有一定发展潜力。
Objective To review the research progress of the osteogenic effect of strontium（Sr） and its application in the orthopaedics.Methods The recent literature concerning the osteogenic effect of Sr and its application in orthopaedics at home and abroad was extensively reviewed,and the research and development were summarized.Results Both in vivo and in vitro studies showed that Sr could enhance bone formation and inhibit bone resorption.Clinically,Sr was applied for treatment of osteoporosis,composite biomaterials in tissue engineering,and treatment of bone tumors and bone metastases.Conclusion Sr is one important combined element of alternative materials in bone tissue engineering,and can strengthen the mechanical and biological properties of the bone replacement material,so it has some development potential in bone tissue engineering.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2012年第11期1398-1402,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
云南省应用基础研究项目(2011FB223)~~
关键词
锶
成骨效应
骨组织工程
Strontium Osteogenic effect Bone tissue engineering
