摘要
目的:观察榄香烯联合吉西他滨、顺铂治疗晚期非小细胞肺癌的疗效及不良反应。方法:采取随机分组法将68例晚期非小细胞肺癌患者分为治疗组和对照组。治疗组34例给予榄香烯联合吉西他滨、顺铂化疗;对照组34例给予吉西他滨、顺铂化疗,21天为一个周期,2-3个周期后评价疗效。结果:治疗组和对照组总有效率分别为44.1%和41.1%,两组间无显著性差异(P>0.05)。但在提高生活质量及减轻骨髓抑制治疗组均优于对照组(P<0.05)。消化道反应及肝、肾功能变化两组无差异。结论:榄香烯联合吉西他滨、顺铂治疗晚期非小细胞肺癌的疗效与单纯化疗相当,但可减轻化疗毒副反应,提高患者的生活质量。
Objective：To observe the curative effect and adverse reaction of elemene combined with gemcitabine and cisplatin in treatment of advanced non small cell lung cancer（NSCLC）.Methods：All 68 advanced NSCLC patients were divided into treatment group and control group randomly,34 cases in the treatment group were given elemene combined with gemcitabine,cisplatin chemotherapy,34 cases in the control group were given gemcitabine,cisplatin chemotherapy.21 days as a cycle,curative effects were evaluated after 2 or 3 cycles.Results：Total efficiency of the treatment group and the control group was 44.1% and 41.1% respectively.There was no significant difference（P〈0.05） between the two groups.But in improving the quality of life and reducing the bone marrow inhibition,the treatment group were better than control group（P〈0.05）.Gastrointestinal reaction,liver and renal function in two groups were almost the same.Conclusion：Compared with chemotherapy alone,elemene combined with gemcitabine,cisplatin therapy has similar curative effect in treatment of advanced NSCLC.Nevertheless,combined chemotherapy can palliate the adverse reaction,and improve patients＇ quality of life.
出处
《现代肿瘤医学》
CAS
2012年第11期2303-2304,共2页
Journal of Modern Oncology
