摘要
目的:比较放疗联合单药化疗与单纯放疗治疗晚期非小细胞肺癌(NSCLC)的近期疗效及不良反应。方法:48例Ⅲ-Ⅳ期非小细胞肺癌,分成对照组(单纯放疗组,RT)21例和治疗组27例(放疗联合单药化疗组,CRT)。治疗组中吉西他滨+12例单纯放疗和长春瑞滨+15例单纯放疗,放疗同期每周予低剂量的吉西他滨或长春瑞滨单药化疗。放疗前均先给予2个周期"紫杉醇+顺铂"方案诱导化疗。两组放疗方法相似。结果:总有效率(ORR)治疗组59.3%(16/27)与对照组42.9%(9/21)无明显差异(χ2=1.27,P=0.259)。Ⅳ期NSCLC中总有效率长春瑞滨+单放病例77.8%(7/9)高于对照组30.8%(4/13)(P=0.08),其余组及Ⅲ期NSCLC各组均未见明显差异。肺损伤及血液毒性发生率治疗组高于单纯放疗组,食管损伤两组均较轻。结论:放疗联合吉西他滨或长春瑞滨治疗Ⅲ/Ⅳ期非小细胞肺癌有望提高近期疗效,毒性反应均可耐受。远期疗效有待进一步随访。
Objective：To compare the recent clinical efficacy and adverse reaction of concurrent radiotherapy and gemcitabine（GEM） or navelbine（NVB） chemotherapy with radiotherapy alone for stage Ⅲ-Ⅳ non-small cell lung cancer（NSCLC）.Methods：All 48 patients with stage Ⅲ-Ⅳ NSCLC enrolled in this study,who were divided into radiotherapy alone group（RT group,21 patients） and chemotherapy combined with radiotherapy group（CRT group,27 patients）.The CRT group（GEM group,12 patients and NVB group,15 cases）received concurrent radiotherapy and low-dose of GEM or NVB chemotherapy.48 patients received two cycles of induction chemotherapy（paclitaxel and cisplatin）.All patients received three-dimensional conformal radiation therapy.Results：The overall response rate（ORR） of the CRT group and the RT group were 59.3%（16/27）and 42.9%（9/21）,respectively（P=0.259）.ORR of NVB＋RT group 77.8%（7/9） was higher than that of RT alone group 30.8%（4/13）in stage Ⅳ NSCLC（P=0.08）.The rest of the groups and all groups in the stage Ⅲ NSCLC were no differences.The toxicity of lung,esophagus and blood in 48 patients were well tolerated and all patients completed their treatment successfully.Conclusion： The radiotherapy combined with gemcitabine or navelbine chemotherapy for stage Ⅲ-Ⅳ non-small cell lung cancer showed better effect and tolerable toxicity.We would further follow up the long-term result of 48 cases.
出处
《现代肿瘤医学》
CAS
2012年第11期2299-2302,共4页
Journal of Modern Oncology
基金
南京军区医学科技创新资助项目(编号:08MA069)
关键词
非小细胞肺癌
吉西他滨
长春瑞滨
放射增敏
同期放化疗
non-small cell lung cancer
gemcitabine/navelbine
radiosensitization
concurrent chemoradiotherapy
