血管源性轻度认知障碍患者hs-CRP、HCY及脑白质损害的相关性研究被引量：12

Study on relationship between hs-CRP,Hcy and cerebral white matter injury in patients with mild vascular cognitive impairment

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摘要目的探讨血管源性轻度认知障碍(vMCI)与血清超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、脑白质损害之间的关系及意义。方法对60例vMCI患者及40例认知功能正常的老年人均进行头颅MRI检查和测定血清HCY、hs-CRP。结果 vMCI患者组Hcy、Hs-CRP均明显高于对照组(P﹤0.01);vMCI组有显著脑白质损害,Hcy、hs-CRP浓度越高,脑白质损害越显著(P﹤0.05)。结论 vMCI与高Hcy、高hs-CRP、脑白质损害有关,Hcy、Hs-CRP是血管源性轻度认知障碍患者的危险因子,且与脑白质损害严重程度相关,测定血清Hcy、Hs-CRP水平对判断vMCI的病情和评价疗效均具有重要意义。 Objective To explore the relationship between hs - CRP, Hcy and cerebral white matter damage in patients with mild vascular cognitive impairment （vMCI） and the significance of their relationship. Methods Sixty patients with vMCI and 40 elder persons with normal cognitive function were examined with cranial MRI scanning and serum Hcy and hs - CRP determination. Results Serum levels of Hey and Hs - CRP in patients with vMCI were significantly higher than those of control group （ P 〈 0.01 ）. Patients in vMCI group had significant cerebral white matter damage （ P 〈 0.05 ）. The higher the concentration of Hey and hs - CRP was, more significant would be the cerebral white matter damage （ P 〈 0.05 ）. Conclusion Vascular cognitive impairment （vMCI） is closely related to high serum Hcy, high hs - CRP and white matter impair- ment, serum Hey and Hs - CRP were risk factors of patients with vascular mild cognitive impairment, and they were related to the severity of cere- bral white matter damage, hence determination of serum levels of Hcy and Hs - CRP is important in evaluation of vMCI condition and efficacy of treatment.

作者朱海生李恩君张桓焦丽敏

机构地区邯郸市中心医院神经内一科邯郸市中心医院普外一科河北医科大学招生办

出处《临床和实验医学杂志》 2012年第21期1699-1700,1702,共3页 Journal of Clinical and Experimental Medicine

关键词血管源性轻度认知障碍超敏C-反应蛋白同型半胱氨酸脑白质损害 Vascular mild cognitive impairment hs - CRP Hcy Cerebral white matter damage

分类号 R749.1 [医药卫生—神经病学与精神病学]

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1Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment[J]. Arch Neurol, 2001,58(12) :1985 - 1992.
2Wahlund LO, Barkhof F, Fazekas F, et al. A new rating scale for age - related white matter changes applicable to MRI and CT [ J ]. Stroke, 2001,32(6) :1318 - 1322.
3Devaraj S, Singh U, Jialal I. The evolving role of C - reactive protein in atherothrombosis[ J ]. Clin Chem, 2009,55 (2) :229 - 238.
4Schmidt R, Schmidt H, Curb JD, et al. Early inflammation and dementia: a 25 - year follow - up of the Honolulu - Asia Aging Study [ J ]. Ann Neurol, 2002,52(2) :168 -174.
5Roberts RO, Geda YE, Knopman DS, et al. Association of C - reactive protein with mild cognitive impairment[J]. Alzheimers Dement, 2009, 5(5) :398 -405.
6Kuo HK, Yen CJ, Chang CH, et al. Relation of C -reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta -analysis [ J ]. Lancet Neurol, 2005,4 (6) : 371 - 380.
7Verma S, Kuliszewski MA, Li SH, et al. C - reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C - reactive protein and cardiovascular disease[ J]. Circulation, 2004,109 ( 17 ) :2058 - 2067.
8Leblhuber F, Walli J, Artner - Dworzak E, et al. Hyperhomocysteinemia in dementia[ J]. J Neural Transm, 2000,107 (12) : 1469 - 1474.
9Ravaglia G, Forti P, Maioli F, et al. Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia[ J]. Exp Gerontol, 2004,39(3) :443 -450.