摘要
为研究人巨细胞病毒感染与冠心病的关系 ,利用人巨细胞病毒磷酸化蛋白PP71基因引物 ,采用聚合酶链反应检测了 5 6例冠心病患者和 42例健康对照者外周血人巨细胞病毒 ,同时应用全自动生物化学仪检测了血清总胆固醇、甘油三酯、载脂蛋白A、载脂蛋白B含量。结果发现冠心病组血人巨细胞病毒阳性率为 5 8.93 % ,显著高于对照组的 2 8.5 7% (P <0 .0 1) ,急性心肌梗死和不稳定型心绞痛患者血人巨细胞病毒的阳性率又高于其他类型冠心病患者 ( 77.2 7%比 47.0 6 % ,P <0 .0 5 ) ,而冠心病患者中人巨细胞病毒阳性者与人巨细胞病毒阴性者各种血脂水平无明显差异。结果提示 ,人巨细胞病毒感染与冠心病发病有关 ,可能是冠心病的一个危险因素 。
Aim To explore the relationship between human cytomegalovirus (hCMV)infection and coronary heart disease (CHD). Methods Peripheral blood specimens from 56 CHD patients and 42 controls were detected by PCR for the presence of hCMV nucleic acid in white blood cell using the hCMV pp71 gene primer pair, and the levels of total cholesterol (TC), triglyceride (TG), apolipoprotein A (Apo A), apolipoprotein B (Apo B) in serum were analyzed simultaneously. Results With the hCMV pp71 gene primer, hCMV nucleic acid was found in 58.93% of the CHD patients and in 28.57% of controls, the difference is significant (P<0.01). The positive rate of hCMV in acute myocardial infarction (AMI) and unstable angina pectoris (UAP) patients is higher than that in the other types of CHD patients(77.27% vs 47.06%, P<0.05). For the CHD patients, no significant difference in the levels of serum TC, TG, Apo A and Apo B was found between hCMV positive ones and hCMV negative ones. Conclusion hCMV infection is relevant to CHD, and may be regard as an risk factor for CHD; CHD patients with hCMV are apt to suffer from AMI and UAP.
出处
《中国动脉硬化杂志》
CAS
CSCD
2000年第2期154-156,共3页
Chinese Journal of Arteriosclerosis
基金
福建省教委科研资金资助!(项目编号:97A094)
