摘要
目的探讨缺氧诱导因子-1α(HIF-1α)和环氧合酶-2(COX-2)在前列腺癌组织中的表达情况及与肿瘤血管形成的关系。方法应用免疫组化(SP)法检测72例不同病理级别前列腺癌组织中HIF-1α、COX-2的表达,用八因子相关抗原(VIII-R-Ag)标记微血管密度(MVD)。结果HIF-1α、COX-2在不同病理级别前列腺癌中表达差异有统计学意义;HIF-1α、COX-2与前列腺癌病理分级存在显著相关性;MVD在不同病理级别前列腺癌组织中差异有统计学意义;HIF-1α、COX-2的表达与MVD存在显著相关性,HIF-1α与COX-2的表达呈正相关。结论HIF-1α和COX-2与前列腺癌的恶性程度有关,并可能在促进肿瘤血管形成过程中起协同作用。
Objective To study the expression of HIF-1αand COX-2 in prostate cancer and its relationship with tumor angiogenesis.Methods The expression of HIF-1αand COX-2 was examined by immunohistochemistry Streptavidin-Peroxidase(SP)method in 72 cases of prostatic carcinoma with different pathological grades,and the MVD was marked out by the VIII-R-Ag.Results There was a statistically significance in the expression differences of HIF-1αand COX-2 in prostatic carcinoma with different pathological grades;significant correlation was showed between HIF-1αand COX-2 and the pathological grading of prostate cancer;the differences of MVD in prostate cancer with different grades hade a statistically significance;the expression of HIF-1αand COX-2 had a significant correlation with MVD,and positive correlation was showed in the expression of HIF-1αand COX-2.Conclusion HIF-1αand COX-2 relate to malignancy of prostate cancer,and have a synergistic effect in tumor angiogenesis process.
出处
《医学研究与教育》
CAS
2012年第5期18-22,共5页
Medical Research and Education
