瑞芬太尼复合异丙酚静脉麻醉在脊柱手术中的临床观察被引量：2

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摘要目的:通过随机分组的对比观察,评价瑞芬太尼复合异丙酚静脉全麻的临床效果及安全性。方法:50例择期手术患者分为瑞芬太尼组(R组)和芬太尼组(F组),每组各25例,诱导采用咪唑安定0.04～0.05mg/kg,R组:瑞芬太尼1～2μg/kg,维库溴铵0.1～0.2mg/kg,异丙酚1～2mg/kg。F组:芬太尼2～2.5μg/kg,维库溴铵0.1～0.2mg/kg,异丙酚1～2mg/kg。维持分别为瑞芬太尼10μg/(kg.h),异丙酚1～3mg/(kg.h)泵输维持;芬太尼1μg/(kg.h),异丙酚1～3mg/(kg.h)泵输。同时吸入66%氧化亚氮和1%异氟醚,MAC保持在0.8～1.5。观察的指标有诱导前、插管前、插管期间、切皮前、切皮后5mi n以及术中每10mi n的血压、心率变化情况。停药后自主呼吸恢复时间、拔管时间和唤之睁眼时间;自主呼吸的潮气量、频率和ETCO2;拔管后即刻、15mi n、30mi n的意识状态(OAAS)和疼痛程度(VAS);苏醒期间出现寒战、肌颤、恶心、呕吐及躁动等不良反应的情况。结果:与芬太尼相比,瑞芬太尼起效快、清除快、呼吸和意识的恢复优于芬太尼,镇痛效果不弱于芬太尼,安全性与芬太尼相似。结论:瑞芬太尼是一种适合用于持续输注的新型阿片类镇痛药,可用于与异丙酚复合的静脉全麻中。

作者王平超

机构地区湖北省汉川市人民医院

出处《中国美容医学》 CAS 2012年第09X期201-202,共2页 Chinese Journal of Aesthetic Medicine

关键词瑞芬太尼芬太尼复合麻醉

分类号 R614 [医药卫生—麻醉学]

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