摘要
目的 :研究甲状腺癌组织中CD15抗原和bcl 2的基因蛋白的表达与肿瘤发生和转移的关系 ,并探讨CD15与bcl 2基因蛋白表达的关系。方法 :应用微波 LSAB免疫组织化学法检测 50例甲状腺癌、4 5例甲状腺腺瘤和 2 0例癌旁正常甲状腺组织中CD15和bcl 2基因蛋白表达。结果 :在甲状腺癌中CD15和bcl 2基因蛋白表达阳性率分别为 6 8 0 %和 4 6 0 % ,均显著高于甲状腺腺瘤和癌旁正常甲状腺组织 (P<0 0 5) ,CD15和bcl 2阳性率均与甲状腺癌淋巴结转移相关 (P <0 0 5) ,与甲状腺癌组织类型无明显关系 (P >0 0 5)。CD15表达与bcl 2表达呈明显正相关性。结论 :CD15和bcl 2表达对预测甲状腺癌转移和评估预后是一种重要参考指标。
Objective:The expression of CD 15 antigen and oncoprotein bcl 2 in thyroid cancer was examined in order to study the correlation between them.Mthods:The expression of CD 15 and bcl 2 in 50 thyroid cancers,20 adjacent noncancerous portion, 45 adenoma and 10 normal thyroid tissue were respectively investigated by Microwave LSAB immunohistochemical technique, Results:The postivie rate of CD 15 and bcl 2 in thyroid cancer was 68 0% and 46 0%,which was significantly higher than that in adenoma or adjacent noncancerous ( P <0 05), The prercentage of CD 15 and bcl 2 positive expression was found to be significantly correlated with the tumor metastasis ( P <0 05),but not correlated with histological feature Expression of CD 15 was significantly correlated with bcl 2 Conclusions:Expression of CD 15 and bcl 2 can be regarded as parameter to evaluate tumor metastasis and prognosis of thyroid cancer
出处
《肿瘤防治杂志》
2000年第2期126-128,共3页
China Journal of Cancer Prevention and Treatment
