摘要
目的探讨肺大细胞癌的临床表现、诊断及预后。方法回顾性分析109例肺大细胞癌患者的临床资料,观察其临床表现、影像学特征,分析临床病理特征与预后的关系。结果 109例患者中男性92例,女性17例;中位年龄58岁。ⅠA期2例,ⅠB期30例、ⅡA期4例、ⅡB期16例、ⅢA期24例、ⅢB期11例,Ⅳ期22例。常见临床表现为咳嗽、咯血、胸痛。影像学表现多为周围型。109例患者的中位生存期为17.9个月,1、2、3年生存率分别为66.1%、25.7%和13.8%。N0、N1患者的中位生存期分别为23.7个月和19.2个月,均高于N2、N3患者的12.8个月和10.1个月(P<0.05),N2、N3患者之间生存期的差异亦有统计学意义(P<0.05)。Ⅰ～ⅢA期和ⅢB～Ⅳ期患者的中位生存期分别为20.9个月和11.5个月,差异有统计学意义(P<0.01)。吸烟指数对生存期无显著影响。结论肺大细胞癌的淋巴结转移及TNM分期情况是与生存密切相关的因素。
Objective To explore the clinical characteristics, diagnosis and prognosis of large cell lung cancer （LCLC）. Methods A retrospective study was performed on the clinical records of 109 patients with LCLC from Shanghai Pulmonary Hospital. The clinical manifestatons and imaging features of the 109 patients were observed, and the relationship between clinical characteristics and prognosis were analyzed. Results There were 92 males and 17 females, and the mean age was 58 years. There were 2 patients at stage I A, 30 at stage IB, 4 at stage ]IA,16 at stage IIB,24 at stage ILIA,11 at stage IIIb and 22 at stage IV when the diagnosis was confirmed. The main clinical symptoms were cough, haemoptysis and chest pain. The imaging features were mainly peripheral type. The median survival of 109 patients was 17.9 months, and 1-, 2- and 3-year survival rates were 66. 1% , 25.7% and 13.8%. The median survival of No and N1 were 23.7 months and 19.2 months, which were longer than those of N2 and N3 patients（ 12. 8 months and 10. 1 months） , with statistical differences （ P 〈 0. 05 ）. There were significant differences between the survival of N2 and N3 patients （ P 〈 0. 05 ）. The median survival was 20. 9 months and 11.5 months for stage I - III A and III B- IV （ P 〈 0. 01 ）. The smoking index had no influence on survival. Conclusion The TNM staging and lymph node metastasis of LCLC are important factors influencing survival.
出处
《临床肿瘤学杂志》
CAS
2012年第10期912-914,共3页
Chinese Clinical Oncology
关键词
肺大细胞癌
临床特征
预后
Large cell lung cancer
Clinical characteristics
Prognosis
