摘要
目的探讨11C-鬼臼毒素(11C-PDT)在肺癌和炎症模型小鼠体内的生物分布,评价11C-PDT作为新型正电子发射断层显像(PET)示踪剂对肺癌与炎症的鉴别价值。方法肺癌模型小鼠和炎症模型小鼠各12只,分别根据示踪剂种类随机等分为两组,于模型小鼠尾静脉注入11C-PDT或18F-氟代脱氧葡萄糖(18F-FDG),注药后60min用井型探测仪测量11C-PDT或18F-FDG小鼠体内的生物分布。结果11C-PDT在肿瘤组织放射性摄取值(%ID/g)高于炎症组织(0.63±0.25 vs.0.29±0.09,P<0.05);18F-FDG的肿瘤组织放射性摄取值高于炎症组织(7.56±1.77 vs.3.83±0.71,P<0.01);11C-PDT和18F-FDG示踪剂在肿瘤组织的放射性摄取值比较,差异有统计学意义(P<0.05)。18F-FDG组炎症对肌肉的放射性摄取值的比值为1.58±0.11,明显高于11C-PDT组的0.73±0.28(P<0.05)。结论11C-PDT具有更高的肿瘤特异性,将来有望作为PET示踪剂用于肺癌和炎症的鉴别诊断。
Objective To investigate the biodistribution of a new PET tracer-^11C-podophyllotoxin（^11C_PDT） in mice model of lung carcinoma and inflammation, and the value of ^11C-PDT to differentiate the two models. Methods The biodistribution of ^11C- PDT was performed in mice model, and ^18 F-FDG was used as control. Twelve mice with lung carcinoma and twelve mice with inflammation were divided into two groups according to the different tracers at random. ^11C-PDT or ^18F-FDG was injected into eoecygeal vein of mice model. The biodistribution of mice for ^11C_PDT and ^18F-FDG were measured with well-gamma detector at 60 rain after injec- tion. Results On the biodistfibution study of ^11C.PDT, the radioactive uptake（ % ID/g） in tumor was higher than that in the inflammation tissue （ 0. 63 ± 0. 25 vs. 0. 29 ± 0. 09, P 〈 0. 05 ） ; the radioactive uptake （ % ID/g） of 18 F-FDG in tumor was also higher than that in the inflammation tissue（ 7. 56 ± 1.77 vs. 3.83 ± O. 71, P 〈 0. 01 ）. The uptake between 11 C-PDT and 18 F-FDG in tumor was of significance（P 〈0.05）. The ratios of inflammation/muscle of tSF-FDG（ 1.58 ±0. 11 ） were higher than those of ^11C-PDT（O. 73 ±0. 28） with statistic significance （ P 〈 0. 05 ）. Conclusion ^11C-PDT is more specific than ^18 F-FDG in tumor tissue, and could be used as PET tracer to differatiate lung carcinoma from inflammation in the future.
出处
《临床肿瘤学杂志》
CAS
2012年第10期865-868,共4页
Chinese Clinical Oncology
