摘要
目的探讨埃索美拉唑对胃溃疡患者炎性状态、细胞免疫和红细胞免疫的影响。方法选取2010年4月～2012年2月于军事医学科学院附属医院进行治疗的84例胃溃疡患者为研究对象,将其随机分为对照组(奥美拉唑组)和观察组(埃索美拉唑组),每组各42例,后将两组患者治疗前及治疗后3、7 d的血清炎性因子及细胞免疫、红细胞免疫指标进行检测及比较。结果观察组治疗后3 d及7 d的血清C反应蛋白(CRP)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)及人转化生长因子β1(TGF-β1)水平均低于对照组,CD3+、CD4+及CD4/CD8均高于对照组,而CD8+则低于对照组,RBC-C3bR、RBC-TRR及RFER均显著高于对照组,而RFIR和RBC-ICR则低于对照组,差异均有统计学意义(均P<0.05)。结论埃索美拉唑对胃溃疡患者炎性状态、细胞免疫和红细胞免疫的影响更为明显,可从一个方面肯定其在本病治疗中的效果。
Objective To study the influence of Esomeprazole for the inflammatory state,cellular immunity and red cell immune of patients with gastric ulcer.Methods 84 patients with gastric ulcer in the hospital affiliated to military medical science from April 2010 to February 2012 were selected as research object,and they were randomly divided into control group（Omeprazole group） and observation group（Esomeprazole group）,with 42 cases in each group,then the indexes of inflammatory state,cellular immunity and red cell immune of two groups before and after the treatment at third and seventh day were detected and compared.Results The CRP,IL-6,IL-8,TNF-α and TGF-β1 of observation group after the treatment at third and seventh day were all lower than those o control group,CD3＋,CD4＋ and CD4/CD8 were all higher than those of control group,CD8＋ were lower than those of control group,RBC-C3bR,RBC-TRR and RFER were all significantly higher than those of control group,RFIR and RBC-ICR were lower than those of control group,there were all significant differences（all P 0.05）.Conclusion The influence of Esomeprazole for the inflammatory state,cellular immunity and red cell immune of patients with gastric ulcer is more obvious,and it can confirm its effect for the disease from a side.
出处
《中国医药导报》
CAS
2012年第30期77-78,83,共3页
China Medical Herald
关键词
埃索美拉唑
胃溃疡
炎性状态
细胞免疫
红细胞免疫
影响
Esomeprazole
Gastric ulcer
Inflammatory state
Cellular immunity
Red cell immune
Influence
