摘要
目的探讨孟鲁司特在小儿轻度哮喘中的应用效果。方法将120例轻度哮喘患儿按照治疗方法的不同分为治疗组和对照组，对照组采用常规治疗，治疗组在对照组的基础上采用孟鲁司特治疗，两组均治疗4周为1个疗程。结果治疗组的总有效率为91．7％，显著高于对照组的73．3％（x2=3．89，P〈0．05）。治疗组的日问和夜间哮喘评分分别为（0．13±0．05）分、（0．12±0．04）分，显著低于对照组的（1．13±0．21）分、（0．43±0．23）分，无症状天数为（17．43±2．87）d，显著长于对照组的（9．34±1．57）d（t=2．32、1．97、5．75，均P〈0．05）。治疗组治疗后的白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、免疫球蛋白E（1gE）分别为（140．5±6．4）ng／L、（40．1±4．9）IU／ml、（105．6±8．8）IU／ml，显著低于对照组的（189．3±9．7）ng/L、（78．6±7．5）IU／ml、（155．4±10．5）IU／ml（t=11．97、8．75、13．56，均P〈0．05）。治疗组的不良反应发生率为13．3％，与对照组的10．0％差异无统计学意义（X2=1．32，P〉0．05）。结论孟鲁司特能够显著改善轻度哮喘患儿的炎性状态，缓解患儿的临床症状，且不良反应少。
Objective To investigate the application effect of montelukast in children with mild asthma. Methods 120 patients with mild asthma were randomly divided into the treatment group and the control group, the control group was given conventional therapy, the treatment group was treated with montelukast on the basis of the control group. Two groups were treated for 4 weeks as a course. Results The total effective rate of treatment group was 91.7% , which was significantly higher than 73.3 % in the control group （ X2 = 3.89, P 〈 0.05 ）. The daytime and nighttime asthma score in the treatment group were （0.13±0.05 ）points, （0.12±0. 04 ） points , which were significantly lower than （ 1. 13±0.21 ） points, （0.43 _＋ 0.23 ） points in the control group. The symptom-free days was （ 17.43±2.87 ） d, which was significantly longer than （9.34±1.57） d in the control group （ t = 2.32,1.97,5.75, all P 〈 0.05 ）. IL-6,TNF-α, IgE in the treatment group after the treatment were （ 140.5 ±6.4） ng/L, （40.1±4.9） IU/ml, （ 105.6 ± 8.8） IU/ml, which were significantly lower than （ 189.3±9.7 ） ng/L, （ 78.6±7.5 ） IU/ml, （ 155.4±10. 5） IU/ml in the control group （t = 11.97,8.75,13.56, all P 〈 0.05）. The incidence rate of adverse reaction in the treatment group was 13.3% and 10% in the control group,there was no significant ditterence （X2 = 1.32,P 〉 0. 05）. Conclusion Montelukast can significantly improve the inflammatory state in children with mild asthma, relieve clinical symptoms, improve the therapeutic effect, and has less adverse reactions.
出处
《中国基层医药》
CAS
2013年第13期1996-1998,共3页
Chinese Journal of Primary Medicine and Pharmacy
