摘要
目的检测超敏C反应蛋白(hs-CRP)、白细胞介素-12(IL-12)、白细胞介素-18(IL-18)在冠心病患者中的表达情况,探讨其临床意义。方法选取我院100例冠心病患者作为观察组,60例正常体检成人作为对照组,检测血清中hs-CRP(免疫比浊法)、IL-12和IL-18(酶联免疫吸附实验法)的含量,比较不同临床特征中的表达差别。结果观察组hs-CRP、IL-12、IL-18的表达量显著高于对照组,hs-CRP、IL-12、IL-18的表达量与病变分型及累及血管的数量有关。线性相关性分析显示hs-CRP、IL-12、IL-18在冠心病患者中的表达呈正相关。结论 hs-CRP、IL-12、IL-18在冠心病患者中高表达,三者在冠心病发生、发展中具有重要的促进作用,hs-CRP、IL-12、IL-18的联合检测对早期判断冠心病患者病变程度具有重要意义。
Objective To detect the expression of hs-CRP,IL-12 and IL-18 in serum of patients with coronary heart disease,and explore their clinical significance.Methods 100 cases of patients with coronary heart disease in our hospital were selected as the observation group.60 healthy persons were taken as control group,and the expression differences of hs-CRP（detected by Immunoturbidimetric assay）,IL-12 and IL-18（detected by enzyme-linked immunosorbent assay） were analyzed.Results hs-CRP,IL-12 and IL-18 expression level of observation group was significantly higher than those of control group,and correlated with coronary heart disease types and coronary artery lesion number.The linear correlation analysis showed that hs-CRP,IL-12,IL-18 expression of the patients with coronary heart disease was positive correlation.Conclusion The level of hs-CRP,IL-12 and IL-18 shows high expression in serum of patients with coronary heart disease,three indexes have promotion effect on occurrence and development of coronary heart disease,the combined detection of three indexes is important to early determine the degree of coronary heart disease.
出处
《中国医药导报》
CAS
2012年第30期59-60,65,共3页
China Medical Herald
