摘要
目的:探讨血液灌流(HP)联合血液透析(HD)对尿毒症透析患者同型半胱氨酸(Hcy)及超敏C反应蛋白、肿瘤坏死因子α等炎症因子的影响。方法选择尿毒症透析患者50例,分为单纯血液透析组(HD组)和血液灌流联合血液透析组(HP+HD组),每组25例,检测治疗前和治疗8w后血清 Hcy及 CRP、TNF-α的水平,同时测定治疗前后血红蛋白的水平。结果 HP+HD组治疗8w后Hcy及CRP、TNF-α的水平均低于HD组治疗后,差异具有统计学异议(P<0.01),HP+HD组治疗8w后血红蛋白较治疗前升高,差异具有统计学异议(P<0.01)。结论 HP联合HD治疗尿毒症患者可有效降低 Hcy水平,并改善微炎症状态,改善贫血。
Objective To evaluate the blood perfusion(HP)combined hemodialysis(HD)in patients with uremia hemodialysis homocysteine(Hcy)and al ergic inflammation,such as c-reactive protein and tumor necrosis factor alpha factor influence.Methods 50 patients with uremia hemodialysis,divided into pure hemodialysis(HD)and blood perfusion combined hemodialysis group(HP+HD group),25 cases in each group,test before and after 8 weeks treatment serum Hcy and CRP,the level of TNF alpha,at the same time to determine the level of hemoglobin before and after the treatment.Results HP+HD group 8 weeks after treatment Hcy and CRP,the level of TNF alpha were lower than that of HD group after treatment,the dif erence statistical y discrepancy(P<0.01),the HP+HD group 8 weeks after treatment hemoglobin was higher,the dif erence statistical y discrepancy(P<0.01).Conclusion HP with HD therapy uremia patients can ef ectively reduce the Hcy level,and improve the inflammatory state,improve anemia.
作者
黄雯静
张敏
孟晓燕
HUANG Wen-jing;ZHANG Min;MENG Xiao-yan(Guangxi Liuzhou City Workers Hospital,Liuzhou Guangxi 545005,China)
