摘要
目的 探讨非胰岛素依赖型糖尿病一般遗传模式。方法 调查 16 0 8名在校儿童非胰岛素依赖型糖尿病上、下 3代家族史 ,收集 2 80个非胰岛素依赖型糖尿病核心家庭 ,进行非胰岛素依赖型糖尿病家系资料分析。结果 非胰岛素依赖型糖尿病患者一级亲属患病率 2 38% ,先证者父母、同胞、子女患病率分别为 2 6 0 0 %、2 44 %、1 2 4% ,高于一般人群患病率 ;Penrose法计算同胞患病率 /同年龄段患病率为 10 17,接近 1/q1/ 2 ;单基因简单分离分析 ,p0 为 0 0 2 44 ,小于 0 10 ;非胰岛素依赖型糖尿病遗传度h2 为 0 5 4。结论 非胰岛素依赖型糖尿病有明显遗传倾向 ,但不符合单基因遗传模式 ,具有多因子遗传特征。
Objective To study the general genetic pattern of non insulin dependent diabetes mellitus patients. Methods 1 608 children were investigated for NIDDM family history, and 280 nuclear families were collected. Results The prevalence rates of NIDDM among first degree relatives (2 38%), the parents (26 00%), the siblings (2 44%) and the offsprings (1 24%) were higher than that in general population respectively. The s/q was 10 17 by Penrose method, which was close to 1/ q 1/2 . The p 0 was 0 024 4 by simple segregation analysis, which was lower than 0 10. The heritability of NIDDM was 0 54, using the Falconer Threshold Model. Conclusion NIDDM has a familial aggregation, but not fit to the mono genetic models. NIDDM has the feature of multifactorial inheritance.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2000年第2期81-82,共2页
Chinese Journal of Preventive Medicine
