摘要
用遗传流行病学方法调查分析了男性消化性溃疡患者及对照者一级亲属消化性溃疡及其它疾病的发病率。消化性溃疡患者亲属中男女性消化性溃疡的发病率分别为8.13%(27/332)和3.37%(10/297),而对照亲属中则分别为2.25%(5/222)和0.43%(1/234)。消化性溃疡病患者男、女亲属患病的相对危险度分别为3.84(P<0.01)和8.12(P<0.05)。用Falconer法计算得男女消化性溃疡的遗传度分别为49.27±8.22%和54.41±9.50%。经分层分析,病例组吸烟又饮酒的男性亲属中消化性溃疡的发病率(10.49%)及遗传度(67.44±11.26%)明显高于不吸烟且不饮酒的亲属(4.60%,25.57±19.21%),提示遗传因素与环境因素在消化性溃疡的发病中具有协同作用。
Genetic epidemiological method was used to investigate the incidence of peptic ulcer (PU) in the first-class blood relatives of patients with PU and those without PU. The incidence rates for PU in male and female in the relatives of PU patients were 8.13% (27/332) and 3.37% (10/297), respectively, while those in the relatives of control patients were 2.25% (5/222) and 0.43% (1/234), the relative risk (RR) being 3.84 (P<0.01) and 8.12 (P<0.05), respectively. Estimated with Falconer's threshold model, the heritabilities (h^2) of PU for male and female relatives were 49.27±8.22% and 54.41±9.50%, respectively. Stratified analyses showed that in male relatives of PU, PU incidence and h^2 were much higher in those who had both the smoking and drinking habits (10.49%, 67.44±11.26%) than in those who had none (4.60%, 25.57±19.21%), suggesting a synergic effect of genetic and environmental risk factors.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1992年第5期278-281,共4页
Chinese Journal of Medical Genetics
