摘要
目的 :探讨软组织多形性透明变性血管扩张性肿瘤的临床病理学特点。方法 :对 2例软组织多形性透明变性血管扩张性肿瘤进行光镜观察和免疫组化检测。结果 :1例为 5 8岁女性 ,表现为颈部皮下缓慢性生长的肿块 ;另 1例为 31岁男性 ,表现为右后腹膜内肿块。眼观 ,肿瘤境界均较清楚 ,镜检 ,显示以下三个特征性的形态学改变 :(1)呈簇状分布扩张性的薄壁血管 ;(2 )分布于扩张血管之间的多形性瘤细胞 ;(3)血管壁、血管周围及瘤细胞之间伴有明显的透明样变性。免疫标记显示 2例肿瘤细胞均表达vimentin ,1例弱阳性表达CD34。随访至今 ,2例均未复发。结论 :软组织多形性透明变性血管扩张性肿瘤是一种低度恶性的软组织肉瘤 ,其组织学起源尚不明了。
Purpose To study the clinicopathological features of pleomorphic hyalinizing angiectatic tumor of soft parts (PHAT). Methods Two cases of PHAT were examined by light microscopy and immunohistochemistry. Results One case occurred in a 58 year old female, presenting as a slowly growing subcutaneous nodule which was located in the cervical area. The other one appeared as a right retroperitoneal mass, arising in a 31 year old male patient. On histological examination, the well circumscribed tumors were characterized by:(1) the presence of clusters of thin walled ectatic vessels; (2) plemorphic neoplastic cells arranged in sheets or cords between those ectatic vessels; (3)prominent perivascular and intercellular hyalinization. Immunohistochemically, both tumors were positive for vimentin, and one tumor also showed weak immunoreactivity to CD34. Follow up imformation showed no signs of local recurrence. Conclusion PHAT is a distinctive low grade sarcoma and the cells origin remains undetermined. Recognizing this new entity is important to avoid confusion with other mimicking lesions.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第1期1-3,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
上海市科学技术委员会资助课题!(No974119025)
