摘要
目的探讨软组织多形性透明变性血管扩张性肿瘤(PHAT)的临床病理特点。方法对1例软组织多形性透明变性血管扩张性肿瘤进行光镜观察和免疫组化检测,并结合相关文献加以分析。结果患者女性,43岁。发现右颈部肿块。巨检:肿瘤境界较清楚。镜检:有3个特征性的形态学改变:①呈簇状分布扩张性的薄壁血管;②分布于扩张血管之间的多形性瘤细胞;③血管壁、血管周围及瘤细胞之间伴有明显的透明样变性。免疫组化:肿瘤细胞vimentin、CD34和VEGF(+),少量CD99(+)。本例随访1年无复发。结论 PHAT是一种低度恶性的软组织肿瘤,其组织学形态有明显特点,起源尚不清楚。熟悉这一软组织新病种对避免误诊为其他类似病变具有重要意义。
Objective To study the clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts （PHAT）. Methods A case of PHAT was examined by light microscopy and immunohistoehemistry. Results A case occurred in a 43-year-old female, appeared as a right subcutaneous nodule. On histological examination, the well- circumscribed tumors were characterized by ① the presence of clusters of thin-walled ecstatic vessels; ② plemorphie neoplastic cells arranged in sheets or cords between those ecstatic vessels; ③ prominent perivascular and intercellular hyalinization. Immunohistochemieally, the tumor was positive for vimentin CD34, VEGF, and CD99. Follow-up data showed no signs of local recurrence. Conclusion PHAT is a distinctive low-grade sarcoma and cellular origin remains to be investigated. Recognizing this new entity is important to avoid confusion with other mimicking lesions.
出处
《诊断病理学杂志》
CSCD
北大核心
2013年第2期94-96,共3页
Chinese Journal of Diagnostic Pathology
关键词
软组织肿瘤
血管扩张
透明变性
Soft tissue neoplasms
Angiectasis
Hyalinization
